Regulation of dynamics in breast cancer stem cells based on molecular clock.
| Project/Area Number |
15K08098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 難治性乳癌 / TNBC / 体内時計 / 操作 / 乳癌幹細胞 / 癌 / 炎症 |
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| Outline of Final Research Achievements |
This study aimed at the development of the new cure that "I controlled the change of the breast cancer stem cell as a controller, and a cancer treated biological clock mechanism". As a result of this study, the rhythm in the day was recognized in the ALDH activity that was the marker of the breast cancer stem cell, and these rhythm was controlled at a transcription level by WNT protein secreted by the cell except the cancer stem cell. The increase metastasis of cancer was controlled when I gave ALDH activity repressor to an index with the rhythm in the day of these ALDH activity. In addition, biological clock mechanism failed with the cancer stem cell, and, As for the failure, it was revealed that a pattern of the breast cancer onset of microRNA which was a stem cell-specific had an influence. I can expect it that these results of research lead to a new cure for intractable breast cancer.
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Report
(3 results)
Research Products
(2 results)
