Optimization of combination therapy with antihypertensive drug to ameliorate side effects of multilinase inhibitors in kidney cancer
| Project/Area Number |
15K08100
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Sojo University (2017)
Kumamoto University (2015-2016) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
平田 純生 熊本大学, 薬学部附属育薬フロンティアセンター, 教授 (10432999)
成田 勇樹 熊本大学, 薬学部, 助手 (40614665)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 腎細胞癌 / 降圧薬 / 分子標的治療薬 / 副作用軽減 / レニンアンジオテンシン / アンジオテンシン受容体拮抗薬 / スニチニブ / 抗腫瘍効果 / ARB / 腎細胞がん / 酸化ストレス |
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| Outline of Final Research Achievements |
The first-line drug in renal cell carcinoma is sunitinib (SU) which is a molecular target drug. Although SU shows hypertension and proteinuria as a side effect, there is also a report that hypertension by SU is related to therapeutic effect. So, it is concerned that treatment of hypertension may hinder antitumor effect. Therefore, we evaluated the antitumor effect, hypertension and proteinuria when using SU with angiotensin II receptor antagonist (ARB) in tumor bearing mice. As a result, it was suggested that hypertension was ameliorated by using ARB olmesartan, and anticancer effect was increased. Therefore, ARB is recommended for hypertension observed in SU therapy against renal cell carcinoma.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Guidelines for treatment of renal injury during cancer chemotherapy 20162017
Author(s)
Horie Shigeo、Oya Mototsugu、Nangaku Masaomi、Yasuda Yoshinari、Komatsu Yasuhiro、Yanagita Motoko、Kitagawa Yuko、Kuwano Hiroyuki、Nishiyama Hiroyuki、Ishioka Chikashi、Takaishi Hiromasa、Shimodaira Hideki、Mogi Akira、Ando Yuichi、Matsumoto Koji、Kadowaki Daisuke、Muto Satoru
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Journal Title
Clinical and Experimental Nephrology
Volume: 22
Issue: 1
Pages: 210-244
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.2016
Author(s)
Yuki Narita, Miki Ueda, Kohei Uchimura, Yutaka Kakizoe, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Terumasa Nakagawa, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Daisuke Kadowaki, Sumio Hirata, Masashi Mukoyama, Kenichiro Kitamura
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Journal Title
Journal of Pharmacological Sciences
Volume: 130
Issue: 2
Pages: 110-116
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effect of a Ferric Citrate Formulation, a Phosphate Binder, on Oxidative Stress in Chronic Kidney Diseases-Mineral and Bone Disorder Patients Receiving Hemodialysis: A Pilot Study2016
Author(s)
Tanaka M, Miyamura S, Imafuku T, Tominaga Y, Maeda H, Anraku M, Yamasaki K, Kadowaki D, Ishima Y, Watanabe H, Okuda T, Itoh K, Matsushita K, Fukagawa M, Otagiri M, Maruyama T
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 39
Issue: 6
Pages: 1000-1006
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The Effect of <i>Yokukansan</i>, a Traditional Herbal Preparation Used for the Behavioral and Psychological Symptoms of Dementia, on the Drug–Metabolizing Enzyme Activities in Healthy Male Volunteers2016
Author(s)
Soraoka H, Oniki K, Matsuda K, Ono T, Taharazako K, Uchiyashiki Y, Kamihashi R, Kita A, Takashima A, Nakagawa K, Yasui-Furukori N, Kadowaki D, Miyata K, Saruwatari J.
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 39
Issue: 9
Pages: 1468-1474
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access
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