• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The Development of optimal dosage of anti-microbial agents based on PK/PD in patients with special pathological conditions

Research Project

Project/Area Number 15K08105
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionKeio University

Principal Investigator

MATSUMOTO Kazuaki  慶應義塾大学, 薬学部(芝共立), 教授 (60733160)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords抗菌薬 / PK/PD / 特殊病態 / 血液透析濾過 / 化膿性髄膜炎
Outline of Final Research Achievements

The development of optimal dosage of anti-microbial agents based on pharmacokinetics/pharmacodynamics (PK/PD) is an urgent issue. This study was acquired and analyzed PK data in patients with special pathological conditions (hemodiafiltration (HDF), meningitis, systemic inflammatory response syndrome (SIRS)). We revealed meropenem and cefazolin PK in patients with HDF, ceftazidime, cefepime, vancomycin and linezolid PK in patients of meningitis, and daptomycin PK in patients of SIRS, and then developed effective and safe dosing regimens for individual patients. The findings are immediately available for clinical setting and really helpful for proper use of anti-microbial agents.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Dosing optimization of meropenem based on a pharmacokinetic analysis in patients receiving hemodiafiltration and an in vitro model2018

    • Author(s)
      Yokoyama Yuta、Nishino Kakine、Matsumoto Kazuaki、Inomoto Yuki、Matsuda Kaori、Nakamura Rin-nosuke、Yasuno Nobuhiro、Kizu Junko
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 24 Issue: 2 Pages: 92

    • DOI

      10.1016/j.jiac.2017.09.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] ダプトマイシンのHPLCを用いた血漿中濃度測定法に関する検討予測の可能性2017

    • Author(s)
      田島彩子、松元一明
    • Organizer
      第61回日本薬学会関東支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] オンライン血液濾過透析時におけるセファゾリン最適投与法の検討2017

    • Author(s)
      土生章太郎、横山雄太、松元一明、安野伸浩、木津純子
    • Organizer
      日本薬学会第137年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] In vitroモデルを用いたメロペネムの血液透析濾過クリアランス予測の可能性.2016

    • Author(s)
      横山雄太、松元一明、木津純子.
    • Organizer
      第65回日本感染症学会東日本地方会学術集会/第63回日本化学療法学会東日本支部総会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 腎機能障害時(透析時)の抗菌薬投与2015

    • Author(s)
      松元一明
    • Organizer
      第64回日本感染症学会東日本地方会学術集会/第62回日本化学療法学会東日本支部総会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2015-10-21
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi