| Project/Area Number |
15K08119
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐野 統 兵庫医科大学, 医学部, 教授 (00196304)
芝崎 誠司 兵庫医療大学, 共通教育センター, 准教授 (50342530)
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| Co-Investigator(Renkei-kenkyūsha) |
Satake Atsushi 関西医科大学, 医学部, 講師 (50412028)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | IL-2 / 免疫複合体 / 関節リウマチ / 制御性T細胞 / 制御性Ｔ細胞 / コラーゲン誘導関節炎 |
|---|
| Outline of Final Research Achievements |
IL-2ICs administration effectively elicited a >2-fold expansion of CD4+Foxp3+ regulatory T cells (Tregs) in peripheral blood cells than that found in control mice. IL-2ICs treatment significantly inhibited arthritis in CIA mice. Histopathological examination of joints revealed inhibited synovial cell proliferation and IL-17, IL-6, TNF-alpha;, but increased FoxP3+ Tregs after IL-2ICs treatment. Flow cytometric examination of spleen cells revealed reduced IFN-gamma;- and IL-17-producing cells, and increased IL-10 producing Tregs after IL-2ICs treatment. The suppressive activities of CD4+CD25+ Tregs induced by IL-2ICs were stronger than those in untreated mice. IL-2ICs inhibit arthritis by augmenting not only Treg numbers, but also Treg functions, which play regulatory roles in autoimmune arthritis..
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