| Project/Area Number |
15K08124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
Imatoh Takuya 国立医薬品食品衛生研究所, 医薬安全科学部, 主任研究官 (20368989)
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| Co-Investigator(Kenkyū-buntansha) |
堀 雄史 浜松医科大学, 医学部附属病院, 薬剤師 (20436786)
川上 純一 浜松医科大学, 医学部附属病院, 教授 (50272539)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 薬剤疫学 / 糖尿病治療薬 / DPP4阻害薬 / 尿路感染症 / 副作用 / 糖尿病薬 |
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| Outline of Final Research Achievements |
We conducted a pharmacoepidemiological study on SGLT2 inhibitors and DPP4 inhibitors which are a new class of anti-diabetes treatment. First, we compared adverse reactions by therapeutic category using JADER. As a result, we observed that combination of DPP4 inhibitors and other anti-diabetic drugs induced the development of hypoglycemia. Next, we assessed the association between DPP4 inhibitors combination therapy and acute pancreatitis using self-controlled case series design. There were no significant association between DPP4 inhibitors combination therapy and development of acute pancreatitis. Finally, we conducted a retrospective cohort study by using health care insurance claims data. The use of DPP4 inhibitors was associated with an increased risk of UTI. Moreover, elderly male patients with prostatic hyperplasia who received DPP4 inhibitors had a higher risk of UTI than SU users without prostatic hyperplasia.
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