Myelination of the regenerated nerve in the central olfactory pathway
Project/Area Number |
15K08131
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General anatomy (including histology/embryology)
|
Research Institution | Shinshu University |
Principal Investigator |
Fukushima Nanae 信州大学, 学術研究院医学系, 准教授 (90334888)
|
Research Collaborator |
KUROIWA Masafumi 信州大学, 大学院生
YOKOUCHI Kumiko 信州大学, 技術専門職員
SUMITOMO Norimi 信州大学, 技術職員
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 神経再生 / 髄鞘形成 |
Outline of Final Research Achievements |
Aacetyl-l-carnitine (ALC) has various neuroprotective effects against neurodegenerative diseases and facilitates myelination of regenerated axons after peripheral nerve injuries. We previously reported that spontaneous regeneration of the lateral olfactory tract (LOT), the main fiber tract of the central olfactory system, consistently occurred in newborn rats and a majority of these regenerated fibers were unmyelinated in neonatally LOT-transected young adult rats. To investigate the effects of ALC treatment on myelination in LOT, neonatal rats were treated with ALC after LOT transection. The study revealed that ALC accelerates myelination of regenerated fibers in neonatally LOT-injured young adult rats and the number of myelinated axons of regenerated fibers was found to be statistically higher in ALC-treated rats compared to control rats.
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Report
(4 results)
Research Products
(3 results)