Analysis of neurotransmitters in the brain of autism model rat

Research Project

Project/Area Number	15K08133
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	General anatomy (including histology/embryology)
Research Institution	Mie University
Principal Investigator	Narita Masaaki 三重大学, 医学系研究科, 教授 (80302404)
Co-Investigator(Kenkyū-buntansha)	江藤みちる (伊田みちる) 三重大学, 医学系研究科, 助教 (80393148)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	自閉症モデル動物 / 自閉症モデルラット / 疾患モデル動物 / 形態学的解析
Outline of Final Research Achievements	Autism is a congenital neurodevelopmental disorder characterized by deficits in social communication and social interaction, and restricted patterns of behavior. The cause of autism is not known, although abnormalities of neurotransmitter have been suggested to date. Previously, we have reported serotonergic abnormalities in the brain of autism using autism model rats. In the present study, we investigated other neurotransmitters such as dopamine and noradrenalin. We found that broad abnormalities of neurotransmitters may exist in the brain of autism.