| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Incretins, which are secreted from enteroendocrine cells upon nutrient ingestion, potentiate insulin secretion from pancreatic β-cells in a glucose-dependent manner. Incretin-related drugs are now widely used for treatment of type 2 diabetes. Previously we have identified Noc2 as an effector molecule for small GTPase Rab3, a molecule important for exocytosis. Noc2 deficient mice exhibited markedly reduced incretin secretion after meal ingestion and abnormal localization of secretory granules in enteroendocrine cells. From analyses using Noc2 deficient mice and incretin-secreting enteroendocrine cell line, we found that Noc2 is involved in the proper localization of secretory granules, thereby plays an important role for normal regulation of incretin secretion.
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