2017 Fiscal Year Final Research Report
The role of Noc2 in incretin secretion
Project/Area Number |
15K08176
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
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Research Institution | Kobe University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
高橋 晴美 神戸大学, 医学研究科, 医学研究員 (50546489)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | インクレチン / 糖尿病 / GLP-1 / GIP / 腸管内分泌細胞 / インスリン / 分泌顆粒 |
Outline of Final Research Achievements |
Incretins, which are secreted from enteroendocrine cells upon nutrient ingestion, potentiate insulin secretion from pancreatic β-cells in a glucose-dependent manner. Incretin-related drugs are now widely used for treatment of type 2 diabetes. Previously we have identified Noc2 as an effector molecule for small GTPase Rab3, a molecule important for exocytosis. Noc2 deficient mice exhibited markedly reduced incretin secretion after meal ingestion and abnormal localization of secretory granules in enteroendocrine cells. From analyses using Noc2 deficient mice and incretin-secreting enteroendocrine cell line, we found that Noc2 is involved in the proper localization of secretory granules, thereby plays an important role for normal regulation of incretin secretion.
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Free Research Field |
分子細胞生物学
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