The role of Noc2 in incretin secretion
Project/Area Number |
15K08176
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
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Research Institution | Kobe University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
高橋 晴美 神戸大学, 医学研究科, 医学研究員 (50546489)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | インクレチン / 糖尿病 / GLP-1 / GIP / 腸管内分泌細胞 / インスリン / 分泌顆粒 / インクレチン分泌 / 開口放出 / 開口分泌 / 膵β細胞 / 血糖値 |
Outline of Final Research Achievements |
Incretins, which are secreted from enteroendocrine cells upon nutrient ingestion, potentiate insulin secretion from pancreatic β-cells in a glucose-dependent manner. Incretin-related drugs are now widely used for treatment of type 2 diabetes. Previously we have identified Noc2 as an effector molecule for small GTPase Rab3, a molecule important for exocytosis. Noc2 deficient mice exhibited markedly reduced incretin secretion after meal ingestion and abnormal localization of secretory granules in enteroendocrine cells. From analyses using Noc2 deficient mice and incretin-secreting enteroendocrine cell line, we found that Noc2 is involved in the proper localization of secretory granules, thereby plays an important role for normal regulation of incretin secretion.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] A novel diphenylthiosemicarbazide is a potential insulin secretagogue for anti-diabetic agent2016
Author(s)
Sugawara k, Honda K, Reien Y, Yokoi N, Seki C, Takahashi H, Minami K, Mori I, Matsumoto A, Nakaya H, Seino S
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Journal Title
PLoS One
Volume: 11
Issue: 10
Pages: e0164785-e0164785
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Chronic Arsenic Exposure Impairs Pancreatic Function.2016
Author(s)
Carmean CM, Kirkley AG, Yokoi N, Hoshikawa R, Honda K, Gheni G, Sugawara K, Takahashi H, Sargis RM, Seino S
Organizer
17th Servier-IGIS Symposium
Place of Presentation
St. Jean-Cap-Ferrat, France
Year and Date
2016-04-05
Related Report
Int'l Joint Research
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