| Project/Area Number |
15K08214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Nara Medical University |
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Principal Investigator |
Ueda Tetsuo 奈良県立医科大学, 医学部, 准教授 (00364068)
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| Co-Investigator(Kenkyū-buntansha) |
車谷 典男 奈良県立医科大学, 医学部, 副学長 (10124877)
刀根 庸浩 奈良県立医科大学, 医学部, 特任助手 (50630498)
緒方 奈保子 奈良県立医科大学, 医学部, 教授 (60204062)
西 智 奈良県立医科大学, 医学部, 学内講師 (70571214)
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| Research Collaborator |
SAEKI Keigo 奈良県立医科大学, 医学部医学科, 教授 (60364056)
OBAYASHI Kenji 奈良県立医科大学, 医学部医学科, 准教授 (30596656)
MIYATA Kimie 奈良県立医科大学, 医学部医学科, 助教 (40596748)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 白内障 / 生体リズム / 非視覚的光情報 / 光照射後瞳孔反応 / 対光反射 / サーカディアンリズム / 網膜 / メラトニン |
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| Outline of Final Research Achievements |
Misalignment of internal biological rhythm and external environment is suggested as a risk factor of various disease. Non-visual light information received at intrinsically photosensitive retinal ganglion cells (ipRGCs) is the most important cue for synchronization of master clock of biological rhythm. As a non-invasive method to assess sensitivity for non-visual information, post illumination pupil response (PIPR) is suggested. Based on the PIPR data among 746 elderly participants of a community-based cohort study, we found significant association between age and baseline-pupil diameter, and positive association between baseline-pupil diameter and sustained pupil diameter. Among 58 cataract patients, we found slightly lower sustained pupil constriction after red light stimulation, and higher sustained pupil constriction after blue light stimulation at one year after cataract surgery compared with baseline measurement before cataract surgery.
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