Attenuation of brain dysfunction by enhancement of the endogenous system in mice.
| Project/Area Number |
15K08218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Meijo University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ストレス / 内因性システム / 脳機能障害 / 脳機能低下 / アセチルコリン受容体 / レジリエンス / 前頭前皮質 / 神経ネットワーク / 豊かな環境 / 精神疾患 |
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| Outline of Final Research Achievements |
In this study, I tried to to develop new strategies for preventing and treating psychiatric diseases by analyzing the stress-induced behavioral changes in mice. Embryonic nicotine exposure through the dam produced attention deficits and enhanced impulsivity at adolescent period. I found that an endogenous peptide and acetylcholine α7 receptor agonist were useful for the animal model with those behaviors. I believe that these results will help to treat the psychiatric patients.
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| Academic Significance and Societal Importance of the Research Achievements |
主に、発達期に受けたストレスが、出生成熟後に、衝動性の亢進や注意機能障害などの行動障害を誘発することをマウスを用いて再現した。その障害には、前頭皮質における長期増強およびグルタミン神経機能低下が関与していることを発見した。この障害の治療薬として、現在臨床で使用されているガランタミンが有効であることを見出した。
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Report
(5 results)
Research Products
(30 results)
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[Journal Article] Cerebellar α6 subunit-containing GABAA receptors: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders. Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mou2018
Author(s)
Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, Nabeshima T.
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Journal Title
Br J Pharmacol.
Volume: 印刷中
Issue: 12
Pages: 2414-2427
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Prenatal Nicotine Exposure Impairs the Proliferation of Neuronal Progenitors, Leading to Fewer Glutamatergic Neurons in the Medial Prefrontal Cortex.2016
Author(s)
Aoyama Y, Toriumi K, Mouri A, Hattori T, Ueda E, Shimato A, Sakakibara N, Soh Y, Mamiya T, Nagai T, Kim HC, Hiramatsu M, Nabeshima T, Yamada K.
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Journal Title
Neuropsychopharmacology
Volume: 41(2)
Issue: 2
Pages: 578-89
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Deletion of SHATI/NAT8L decreases the N-acetylaspartate content in the brain and induces behavioral deficits, which can be ameliorated by administering N-acetylaspartate.2015
Author(s)
Toriumi K, Mamiya T, Song Z, Honjo T, Watanabe H, Tanaka J, Kondo M, Mouri A, Kim HC, Nitta A, Fukushima T, Nabeshima T.
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Journal Title
Eur Neuropsychopharmacol.
Volume: 25(11)
Issue: 11
Pages: 2108-17
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Prenatal nicotine exposure impairs the proliferation of neuronal progenitors, leading to fewer glutamatergic neurons in the medial prefrontal cortex2016
Author(s)
Takayoshi Mamiya, Shota Tanase, Yuki Aoyama, Kazuya Toriumi, Akihiro Mouri, Tomoya Hattori, Eriko Ueda, Akane Shimato, Nami Sakakibara, Yuka Soh, Taku Nagai, Hyoung-Chun Kim, Kiyofumi Yamada, Masayuki Hiramatsu, Toshitaka Nabeshima
Organizer
30th The International College of Neuropsychopharmacology (CINP) World Congress
Place of Presentation
Seoul, Korea
Year and Date
2016-07-03
Related Report
Int'l Joint Research
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[Book] 疾患薬理学2016
Author(s)
成田年（監修） 間宮隆吉ら（分担）
Total Pages
862
Publisher
ネオメディカル
Related Report
