Abnormalities of mitotic-kinase-mediated signal transduction and diseases
Project/Area Number |
15K08324
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Aichi Cancer Center Research Institute |
Principal Investigator |
Goto Hidemasa 愛知県がんセンター(研究所), 腫瘍医化学部, 室長 (20393126)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 分裂期キナーゼ / Aurora-A / Plk1 / Ndel1 / 分裂間期 / 分裂期 / キナーゼ / 中心体 / がん / シリア病 |
Outline of Final Research Achievements |
Aurora-A and Plk1 are known to be activated in mitosis. Recently, it was reported that these mitotic kinases also function in interphase. Abnormalities of these interphase functions are considered to be related to several diseases, such as cancer or ciliopathy, but the precise mechanisms remain unknown. In this research project, we found that Ndel1 functions upstream of Aurora-A in interphase. Since Ndel1-hypomorphoc mice exhibit ciliopathy-related disorders, these findings shed light on the pathogenesis of ciliopathy.
|
Report
(4 results)
Research Products
(14 results)
-
-
-
[Journal Article] Desmin phosphorylation by Cdk1 is required for efficient separation of desmin intermediate filaments in mitosis and detected in murine embryonic/newborn muscle and human rhabdomyosarcoma tissues.2016
Author(s)
Makihara H., Inaba H., Enomoto A., Tanaka H., Tomono Y., Ushida K., Goto M., Kurita K., Nishida Y., Kasahara K., Goto H., and Inagaki M.
-
Journal Title
Biochem. Biophys. Res. Commun.
Volume: 478
Issue: 3
Pages: 1323-1329
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.2016
Author(s)
Inaba H, Goto H, Kasahara K, Kumamoto K, Yonemura S, Inoko A, Yamano S, Wanibuchi H, He D, Goshima N, Kiyono T, Hirotsune S, Inagaki M.
-
Journal Title
J Cell Biol.
Volume: 212
Issue: 4
Pages: 409-423
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Cytokinetic failure-induced tetraploidy develops into aneuploidy, triggering skin aging in phospho-vimentin deficient mice.2015
Author(s)
Tanaka, H., Goto, H., Inoko, A., Makihara, H., Enomoto, A., Horimoto, K., Matsuyama, M., Kurita, K., Izawa, I., and Inagaki, M.
-
Journal Title
J. Biol. Chem.
Volume: 290
Issue: 21
Pages: 12984-12998
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-