Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
Aurora-A and Plk1 are known to be activated in mitosis. Recently, it was reported that these mitotic kinases also function in interphase. Abnormalities of these interphase functions are considered to be related to several diseases, such as cancer or ciliopathy, but the precise mechanisms remain unknown. In this research project, we found that Ndel1 functions upstream of Aurora-A in interphase. Since Ndel1-hypomorphoc mice exhibit ciliopathy-related disorders, these findings shed light on the pathogenesis of ciliopathy.
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