| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Behcet's disease and sarcoidosis both are HLA-associated ocular diseases. It is well established that Behcet's disease and sarcoidosis are strongly associated with HLA-B*51 allele and some HLA-DRB1 alleles, respectively. Recent studies have reported that gene-gene interactions between HLA risk alleles and other risk genes are observed in HLA-associated diseases, leading to increase the risk of the diseases. In this study, we performed a genome-wide investigation of gene-gene interactions between HLA risk alleles and other genes in Behcet's disease and sarcoidosis. Our genome-wide gene-gene interaction analysis identified several candidate genes which interact with HLA risk alleles of Behcet's disease and sarcoidosis.
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