Genome-wide investigation of gene-gene interactions in HLA-associated ocular diseases
Project/Area Number |
15K08331
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human genetics
|
Research Institution | Yokohama City University |
Principal Investigator |
Yasumura Reiko 横浜市立大学, 医学研究科, 客員研究員 (80534362)
|
Co-Investigator(Kenkyū-buntansha) |
目黒 明 横浜市立大学, 医学研究科, 特任准教授 (60508802)
水木 信久 横浜市立大学, 医学研究科, 教授 (90336579)
|
Research Collaborator |
NANBA Reiko
SATO Mayuki
|
Project Period (FY) |
2015-10-21 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | ベーチェット病 / サルコイドーシス / HLA / 遺伝子間相互作用 |
Outline of Final Research Achievements |
Behcet's disease and sarcoidosis both are HLA-associated ocular diseases. It is well established that Behcet's disease and sarcoidosis are strongly associated with HLA-B*51 allele and some HLA-DRB1 alleles, respectively. Recent studies have reported that gene-gene interactions between HLA risk alleles and other risk genes are observed in HLA-associated diseases, leading to increase the risk of the diseases. In this study, we performed a genome-wide investigation of gene-gene interactions between HLA risk alleles and other genes in Behcet's disease and sarcoidosis. Our genome-wide gene-gene interaction analysis identified several candidate genes which interact with HLA risk alleles of Behcet's disease and sarcoidosis.
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Report
(4 results)
Research Products
(12 results)