| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The tissue phosphoproteomic examination of IgG4-related sclerosing cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC) revealed that the expression profiles of phosphopeptides discriminated IgG4-SC from PSC better than those of non-phosphopeptides. In the pathway analysis, three immunological pathways activated in IgG4-SC appeared to be all B-cell- or immunoglobulin-related. On immunostaining, two highly up-regulated immunological markers in IgG4-SC were expressed mainly in M2-type macrophages, suggesting increased phagocytotic activity induced by the IgG-Fc-gamma receptor interaction. In addition, those molecules were also strongly expressed in other organ manifestations of IgG4-related disease. In conclusion, this study highlighted crucial roles of B cells and macrophages in IgG4-SC, and also identified potential tissue diagnostic markers for IgG4-related disease.
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