Global phosphoproteome analysis of IgG4-related sclerosing cholangitis
Project/Area Number |
15K08345
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Kobe University |
Principal Investigator |
Zen Yoh 神戸大学, 医学研究科, 特命教授 (90377416)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | IgG4 / 硬化性胆管炎 / プロテオーム / リン酸化 / 自己免疫性膵炎 / マクロファージ / プロテオミクス / バイオマーカー |
Outline of Final Research Achievements |
The tissue phosphoproteomic examination of IgG4-related sclerosing cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC) revealed that the expression profiles of phosphopeptides discriminated IgG4-SC from PSC better than those of non-phosphopeptides. In the pathway analysis, three immunological pathways activated in IgG4-SC appeared to be all B-cell- or immunoglobulin-related. On immunostaining, two highly up-regulated immunological markers in IgG4-SC were expressed mainly in M2-type macrophages, suggesting increased phagocytotic activity induced by the IgG-Fc-gamma receptor interaction. In addition, those molecules were also strongly expressed in other organ manifestations of IgG4-related disease. In conclusion, this study highlighted crucial roles of B cells and macrophages in IgG4-SC, and also identified potential tissue diagnostic markers for IgG4-related disease.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Gastrointestinal manifestation of immunoglobulin G4-related disease: clarification through a multicenter survey.2017
Author(s)
Notohara K, Kamisawa T, Uchida K, Zen Y, Kawano M, Kasashima S, Sato Y, Shiokawa M, Uehara T, Yoshifuji H, Hayashi H, Inoue K, Iwasaki K, Kawano H, Matsubayashi H, Moritani Y, Murakawa K, Oka Y, Tateno M, Okazaki K, Chiba T.
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Journal Title
J Gastroenterol
Volume: -
Issue: 7
Pages: 845-853
DOI
Related Report
Peer Reviewed
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[Journal Article] CD133 expression in well-differentiated pancreatic neuroendocrine tumors: a potential predictor of progressive clinical courses.2017
Author(s)
Sakai Y, Hong SM, An S, Kim JY, Corbeil D, Karbanová J, Otani K, Fujikura K, Song KB, Kim SC, Akita M, Nanno Y, Toyama H, Fukumoto T, Ku Y, Hirose T, Itoh T, Zen Y.
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Journal Title
Hum Pathol
Volume: 61
Pages: 148-157
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatic angiomyolipomas may overexpress TFE3, but have no relevant genetic alterations.2017
Author(s)
Jimbo N, Nishigami T, Noguchi M, Iijima H, Hirota S, Tajiri T, Inoue T, Hirose T, Itoh T, Zen Y.
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Journal Title
Hum Pathol
Volume: 61
Pages: 41-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Kanzawa M, Sanuki T, Onodera M, Fujikura K, Itoh T, Zen Y.2017
Author(s)
Kanzawa M, Sanuki T, Onodera M, Fujikura K, Itoh T, Zen Y.
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Journal Title
Pathol Int
Volume: 67
Issue: 2
Pages: 91-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Estimation of the number of histological diagnosis for IgG4-related kidney disease referred to the data obtained from the Japan Renal Biopsy Registry (J-RBR) questionnaire and cases reported in the Japanese Society of Nephrology Meetings2016
Author(s)
Nakashima H, Kawano M, Saeki T, Ubara Y, Hisano S, Nagata M, Zen Y, Yanagita M, Yamaguchi Y, Nishi S, Saito T
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Journal Title
Clin Exp Nephrol
Volume: NA
Related Report
Peer Reviewed
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[Journal Article] A case of intravascular lymphoma diagnosed in an explanted liver after liver transplantation2015
Author(s)
Kuramitsu K, Fukumoto T, Yano Y, Hirano H, Misumi T, Katayama Y, Kawano H, Yakushijin K, Zen Y, Itoh T, Ku Y
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Journal Title
Transpl Int
Volume: 28
Issue: 10
Pages: 1245-50
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases2015
Author(s)
Schlitter AM, Jang KT, Klöppel G, Saka B, Hong SM, Choi H, Offerhaus GJ, Hruban RH, Zen Y, Konukiewitz B, Regel I, Allgäuer M, Balci S, Basturk O, Reid MD, Esposito I, Adsay V
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Journal Title
Mod Pathol
Volume: 28
Issue: 9
Pages: 1249-64
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Intraductal tubulopapillary neoplasm of the bile duct: A case report and review of the published work2015
Author(s)
Nakagawa T, Arisaka Y, Ajiki T, Fujikura K, Masuda A, Takenaka M, Shiomi H, Okabe Y, Fukumoto T, Ku Y, Azuma T, Zen Y
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Journal Title
Hepatol Res
Volume: NA
Issue: 7
Pages: 713-718
DOI
Related Report
Peer Reviewed
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