|Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|Outline of Final Research Achievements
It is hypothesized that dysregulation of microRNA (miR) due to chronic inflammation is one of the possible mechanism in ulcerative colitis (UC) -associated carcinogenesis. We analyzed expression levels of several miRs in surgically resected UC-associated neoplasia and sporadic colon cancer tissues. Our study shows that miRs 20a and 93 are gradually upregulated whereas miRs 21 and 93 are downregulated in inflammatory mucosa through dysplasia to invasive cancer in UC. In addition, miR 20a levels are significantly lower in UC-associated cancer than sporadic cancer. The expression levels of such miRs may be promising useful markers in UC patients for estimating an individual risk for the development of colon cancer. Furthermore, those miRs are potential targets for future chemopreventive approaches in the high-risk population of UC-associated carcinogenesis.