Analysis of ADAM28 activity mechanism on the cell surface
| Project/Area Number |
15K08409
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | National Defense Medical College (2016-2017)
Keio University (2015) |
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Principal Investigator |
Mochizuki Satsuki 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 外科学, 助教 (80365428)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ＡＤＡＭ２８ / 分子標的薬 / 肺癌 / 増殖 / 転移 / ADAM28 / 活性阻害 / 癌細胞増殖 / ADAM / 分子標的治療 |
|---|
| Outline of Final Research Achievements |
We developed a human neutralizing anti-ADAM28 antibody (211-14) from human combinatorial antibody library, and showed that it inhibits ADAM28 activity and IGF-I-induced carcinoma cell proliferation and migration, leading to elongation of survival rate of mice. In addition, combination therapy of antibody 211-14 and docetaxel more effectively improved the survival time than that of bevacizumab and docetaxel.
All these data suggest that our neutralizing antibody 211-14 may be a useful ADAM28 inhibitor for treatment of the non-small cell lung carcinoma patients in the future.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Disentangling the prognostic heterogeneity of stage III colorectal cancer through histologic stromal categorization2018
Author(s)
Ueno H, Sekine S, Oshiro T, Kanemitsu Y, Hamaguchi T, Shida D, Takashima A, Ishiguro M, Ito E, Hashiguchi Y, Kondo F, Shimazaki H, Mochizuki S, Kajiwara Y, Shinto E, Yamamoto J, Shimada Y
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Journal Title
Surgery
Volume: 163
Issue: 4
Pages: 777-783
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Desmoplastic Pattern at the Tumor Front Defines Poor-prognosis Subtypes of Colorectal Cancer2017
Author(s)
Ueno H, Kanemitsu Y, Sekine S, Ishiguro M, Ito E, Hashiguchi Y, Kondo F, Shimazaki H, Mochizuki S, Kajiwara Y, Shinto E, Yamamoto J.
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Journal Title
Am J Surg Pathol.
Volume: 41
Issue: 11
Pages: 1506-1512
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer.2016
Author(s)
Caroline Rudnicka, Satsuki Mochizuki,Yasunori Okada, Claire McLaughlin, Peter J. Leedman, Lisa Stuart, Michael Epis, Gerard Hoyne, Sherif Boulos, Liam Johnson, Markus Schlaich and Vance Matthews
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Journal Title
Medicine (Baltimore)
Volume: 95
Issue: 40
Pages: e5085-e5085
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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