Development of anti-hepatitis virus strategy based on proteomics
Project/Area Number |
15K08493
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Virology
|
Research Institution | University of Yamanashi |
Principal Investigator |
MORIISHI Kohji 山梨大学, 大学院総合研究部, 教授 (90260273)
|
Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Atsuya 山梨大学, 大学院総合研究部, 助教 (00334871)
KASAI Hirotake 山梨大学, 大学院総合研究部, 助教 (20324189)
TANAKA Tomohisa 山梨大学, 大学院総合研究部, 助教 (30585310)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | HCV / C型肝炎 / HBV / B型肝炎 / 抗ウイルス剤 / 宿主蛋白質 / 宿主因子 / 抗ウイルス化合物 |
Outline of Final Research Achievements |
The aim of this study was identification of antiviral compounds that targeted host agents interacting proteins of hepatitis B and C viruses (HBV and HCV) based on proteomics information. FKBP6 and HM13 were identified as essential host proteins for HCV replication and the viral particle production and its pathogenicity. DM-CHX and cinnamic acid derivatives, which target them, prevented HCV replication and production. Furthermore, pTEFb inhibitor could suppress HBV replication and production. These results will contribute to development of novel antiviral agents targeting production and pathogenicity of HBV and HCV
|
Report
(4 results)
Research Products
(26 results)
-
-
[Journal Article] Cinnamic acid derivatives inhibit hepatitis C virus replication via the induction of oxidative stress.2017
Author(s)
Amano R, Yamashita A, Kasai H, Hori T, Miyasato S, Saito S, Yokoe H, Takahashi K, Tanaka T, Otoguro T, Maekawa S, Enomoto N, Tsubuki M, Moriishi K.
-
Journal Title
Antiviral Research
Volume: 145
Pages: 123-130
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx2016
Author(s)
Kouwaki T, Okamoto T, Ito A, Sugiyama Y, Yamashita K, Suzuki T, Kusakabe S, Hirano J, Fukuhara T, Yamashita A, Saito K, Okuzaki D, Watashi K, Sugiyama M, Yoshio S, Standley DM, Kanto T, Mizokami M, Moriishi K, Matsuura Y
-
Journal Title
J Virol
Volume: 90
Issue: 7
Pages: 3530-3542
DOI
Related Report
Peer Reviewed
-
[Journal Article] Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation2016
Author(s)
T. Tanaka, K. Okuyama-Dobashi, S. Murakami, W. Chen, T. Okamoto, K. Ueda, T. Hosoya, Y. Matsuura, A. Ryo, Y. Tanaka, M. Hagiwara and K. Moriishi
-
Journal Title
Antiviral Research
Volume: 133
Pages: 156164-156164
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Involvement of FKBP6 in hepatitis C virus replication.2015
Author(s)
Kasai H, Kawakami Y, Yokoe H, Yoshimura K, Matsuda M, Yasumoto J, Maekawa S, Yamashita A, Tanaka T, Ikeda M, Kato N, Okamoto T, Matsuura Y, Sakamoto N, Enomoto N, Takeda S, Fujii H, Tsubuki M, Kusunoki M, Moriishi K.
-
Journal Title
Scientific reports
Volume: 5
Issue: 1
Pages: 16699-16699
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Identification of antiviral agents targeting hepatitis B virus promoter from extracts of Indonesian marine organisms by a novel cell-based screening assay.2015
Author(s)
Yamashita A, Fujimoto Y, Tamaki M, Setiawan A, Tanaka T, Okuyama-Dobashi K, Kasai H, Watashi K, Wakita T, Toyama M, Baba M, de Voogd NJ, Maekawa S, Enomoto N, Tanaka J, Moriishi K
-
Journal Title
Marine Drug
Volume: 13
Issue: 11
Pages: 6759-6773
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.2015
Author(s)
Okuyama-Dobashi K, Kasai H, Tanaka T, Yamashita A, Yasumoto J, Chen W, Okamoto T, Maekawa S, Watashi K, Wakita T, Ryo A, Suzuki T, Matsuura Y, Enomoto N, Moriishi K.
-
Journal Title
Scientific reports
Volume: 5
Issue: 1
Pages: 17047-17047
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Deep sequencing and phylogenetic analysis of variants resistant to interferon-based protease inhibitor therapy in chronic hepatitis induced by genotype 1b hepatitis C virus.2015
Author(s)
Sato M, Maekawa S, Komatsu N, Tatsumi A, Miura M, Muraoka M, Suzuki Y, Amemiya F, Takano S, Fukasawa M, Nakayama Y, Yamaguchi T, Uetake T, Inoue T, Sato T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N.
-
Journal Title
J Virol
Volume: 89(11)
Issue: 11
Pages: 6105-16
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Presentation] CDK9 inhibitor FIT-039 suppresses HBV propagation2016
Author(s)
Moriishi K, Tanaka T, Okuyama-Dobashi K, Chen W, Okamoto T, Ueda K, Hosaya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M
Organizer
第64回日本ウイルス学会総会
Place of Presentation
札幌コンベンションセンター(札幌白石区)
Year and Date
2016-10-23
Related Report
Int'l Joint Research
-
-
-
-
-
-
[Presentation] Metachromin A, sesquiterpene from marine sponge Dactylospongia metachromia, exerts anti-HBV activity via inhibition of HBV core promoter2015
Author(s)
Atsuya Yamashita, Tomohisa Tanaka, Kaori Okuyama-Dobashi, Hirotake Kasai, Koichi Watashi, Takaji Wakita,, Masaaki Toyama, Masanori Baba, Mayumi Tamaki, Junichi Tanaka, Kohji Moriishi
Organizer
日本ウイルス学会
Place of Presentation
福岡国際会議場(福岡県福岡市)
Year and Date
2015-11-22
Related Report
-
-
-
-
-
-