| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To clarify the role of AIM (Apoptosis inhibitor of macrophage) in neuroimmuno-inflammation, we established a mouse model of Alzheimer disease (AD). As a model of human AD, we generated APP (amyloid precursor protein) transgenic mice which have 4 different mutations on human APP gene (the mutations are originally seen in some types of human AD patients), and confirmed that those mice have Aβ accumulation in their brain. We expect that those mice should be a strong tool for analyzing roles of AIM in AD pathology.
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