Characterization of novel Capnocytophaga spp. isolated from septic patients
Project/Area Number |
15K08662
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
|
Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
SUZUKI MICHIO 国立感染症研究所, 獣医科学部, 主任研究官 (00392324)
|
Research Collaborator |
IMAOKA KOICHI
KIMURA MASANOBU
|
Project Period (FY) |
2015-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 新規Capnocytophaga属菌 / Capnocytophaga / C. canis / C. canimorsus / イヌ口腔内細菌 / ネコ口腔内細菌 / 薬剤感受性 / 遺伝子解析 / C. camimorsus / C. cynodegmi / 全ゲノム解析 / 質量分析法 |
Outline of Final Research Achievements |
After 2011, we isolated three strains of Capnocytophaga sp. from septic patients in Japan following a cat scratch, cat bite, or close contact with a dog. We demonstrated that these three strains of Capnocytophaga sp. belonged to C. canis, which is novel species reported in 2016. We analyzed these strains of C. canis and established a specific PCR which can specifically detect C. canis. In addition, the prevalence of C. canis in dogs and cats was determined using this PCR method. As a result, C. canis was detected in 55% of dogs and 66% of cats.
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Academic Significance and Societal Importance of the Research Achievements |
動物由来のカプノサイトファーガ感染症は、イヌやネコによる咬・掻傷に伴って感染し、重症化して敗血症に至ると約30%が死亡する。国内では1993年から2017年末までに計93例(うち死亡19例)が確認されている。我々は今回、世界初の報告となるCapnocytophaga canisによる敗血症例3例から分離された菌株を詳細に解析し、C. canisの検査・診断法を確立するとともに、常在菌として保有するイヌ・ネコの保菌率を明らかにした。これらの研究成果は、C. canisの公衆衛生上のリスク分析に貢献するものであり、今後の研究の進展に重要な役割を果たすことが期待される。
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Report
(5 results)
Research Products
(22 results)