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ATP could cause visceral pain released from inflammation cells at the serosal side of urinary bladder in partial bladder outlet obstruction rat model

Research Project

Project/Area Number 15K08664
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionAkita University

Principal Investigator

KAWATANI MASAHITO  秋田大学, 医学(系)研究科(研究院), 教授 (00177700)

Co-Investigator(Kenkyū-buntansha) 林田 健一郎  秋田大学, 医学(系)研究科(研究院), 准教授 (40769634)
伊藤 登茂子  秋田大学, 医学(系)研究科(研究院), 教授 (50241675)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords膀胱痛 / 過活動膀胱 / ATP / 尿道狭窄モデル / 神経科学 / シグナル伝達 / 生理活性
Outline of Final Research Achievements

Size of the rat urinary bladder enlarge after partial bladder outlet obstruction (pBOO). Nerve fibers were diminished from the mucosa and submucosa and remained serosa area. Fibroblast and blood cells were observed at submucosa and area between smooth muscle and serosa membrane. ATP was measured from mucosal side or serosal side Ussing chamber. 2 weeks after pBOO operation, 3-6pM ATP was detected from mucosal side which 2-4 times higher at serosal side. ATP increase when the pressure increased. Following removal of the mucosa, ATP was not increase at control animal, however, increased pressure dependently at pBOO. Pelvic nerve afferent activity after removal of mucosa was detected 30cmH2O in control animal In pBOO, activity was first detected at 10cmH2O and its frequency increase with pressure.
In conclusion, ATP from connective tissue could activate smooth muscle and nerve terminals around the serosal contribute visceral pain.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (2 results)

  • [Journal Article] 排尿反射から見た脊髄の機能的回路2018

    • Author(s)
      河谷正仁 河谷昌泰
    • Journal Title

      Clinical Neuroscience

      Volume: 36 Pages: 41-48

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noradrenergic effects in rat sacral autonomic nucleus using in vitro slice patch-clamp recording.2017

    • Author(s)
      Kawatani, M., Akimoto, N., Yamada, A., Furue, H., Kawatani, M
    • Journal Title

      Biomedical Res

      Volume: 38 Pages: 359-369

    • NAID

      130006248350

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] セロトニン受容体による排尿機能制御2017

    • Author(s)
      宮井和政 河谷正仁
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 6 Pages: 159-164

    • NAID

      40021296399

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATP release from bladder urothelium and serosa in a rat model of partial bladder outlet obstruction.2016

    • Author(s)
      Shiina M, Hayashida K, Ishikawa K, Kawatani M
    • Journal Title

      Biomedical Res

      Volume: 37 Pages: 299-304

    • NAID

      130005432961

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serotonergic regulation of distention-induced ATP release from the urothelium.2016

    • Author(s)
      Matsumoto-Miyai, K.,  Yamada, E., Shinzawa, E., Koyama,Y., Shimada, S., Yoshizumi, M., Kawatani, M.
    • Journal Title

      Am J Renal Physiol

      Volume: 310

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Regulatory effects of 5-Hydorosytryptamine receptors of voiding funciton.2015

    • Author(s)
      Matsumoto-Miyai, K., Yoshizumi, M., Kawatani, M.
    • Journal Title

      Advances in Therapy

      Volume: 32,Supple 1,

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 覚醒下ラットにおけるグリシン髄腔内投与覚醒下ラットにおけるグリシン髄腔内投与による排尿機能抑制効果とグリシン受容体α3サブユニットの関与2015

    • Author(s)
      善積克,河谷正仁
    • Organizer
      第22回日本排尿機能学会
    • Place of Presentation
      札幌
    • Year and Date
      2015-09-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 下部尿路から脊髄入力する痛覚伝達機構のin vivo解析2015

    • Author(s)
      秋元 望, 箱崎敦志, 河谷正仁, 井本敬二, 古江秀昌
    • Organizer
      第37回日本疼痛学会
    • Place of Presentation
      熊本
    • Year and Date
      2015-07-03
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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