Image fusion using a novel multi-modal imaging marker

• Project/Area Number: 15K08707
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Ose Takayuki 国立研究開発法人理化学研究所, 生命機能科学研究センター, 専門技術員 (70519404)
• Co-Investigator(Kenkyū-buntansha): 渡部 浩司 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (40280820) ; 林 拓也 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (50372115)
• Research Collaborator: Nakajima Iwao
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: multi-modal registration / fiducial marker / MRI / PET / CT / surface mapping / Multi-modal registration / multimodal imaging / registration / 画像位置合わせ / マルチモーダル

Outline of Final Research Achievements

The aim of this study is to develop and evaluate the technology related to the alignment of diagnostic images of different modalities such as PET images and MRI images using multimodal markers. We demonstrated that the material of multi-modal marker which we developed has high contrast in CT and PET/Tx images and has sufficient contrast in both T1w-MRI and T2w-MRI, compared to general MRI contrast agents. We also developed the marker-based registration software and marker containers. This research enabled us to register across different modalities of imaging more easily and accurately than the general software-only method.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により簡便かつ高精度の点列位置合わせ法が可能になると考えられる。これまで見過ごされてきた位置合わせの信頼性向上、高精度化、精度評価が可能となり、マルチモーダル画像を用いた医学研究や放射線画像診断能の高精度化を図ることができる。

Research Products

• [Journal Article] A novel Tungsten-based fiducial marker for multi-modal brain imaging (2019)
  • Author(s): Ose Takayuki、Autio Joonas A.、Ohno Masahiro、Nishigori Kantaro、Tanki Nobuyoshi、Igesaka Ami、Mori Tomoko、Doi Hisashi、Wada Yasuhiro、Nakajima Iwao、Watabe Hiroshi、Hayashi Takuya
  • Journal Title: Journal of Neuroscience Methods Volume: － Pages: 22-31
  • DOI: 10.1016/j.jneumeth.2019.04.014
  • Peer Reviewed
• [Presentation] Image fusion using a novel multi-modal imaging marker (2016)
  • Author(s): 合瀬 恭幸
  • Organizer: NRM2016
  • Place of Presentation: Boston Mass, United States
  • Int'l Joint Research
• [Presentation] マルチモーダルマーカーによる診断画像の位置合わせに関する研究 (2015)
  • Author(s): 合瀬恭幸
  • Organizer: 第5回核医学画像解析研究会
  • Place of Presentation: 東北大学サイクロトロン・ラジオアイソトープセンター（宮城県仙台市）
  • Year and Date: 2015-12-12