| Project/Area Number |
15K08730
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山縣 然太朗 山梨大学, 大学院総合研究部, 教授 (10210337)
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| Research Collaborator |
YOKOYAMA Tetsuji
MOCHIZUKI Mie
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | インフルエンザ / 重症化 / 小児 / 肺炎 / 脳炎 / 脳症 / 熱性けいれん / ARDS / 入院 / 急性呼吸窮迫症候群（ARDS) / インフルエンザ脳症 / インフルエンザ脳炎 / ビッグデータ / インフルエンザワクチン / インフルエンザ罹患 / ポアソン回帰モデル / 時系列分析 / 死亡 / 急性呼吸促迫症候群（ARDS) / 急性呼吸促迫症候群(ARDS) |
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| Outline of Final Research Achievements |
In Japan point-of-care tests are routinely used to diagnose influenza. We calculated the incidence of hospitalization in influenza-positive patients with acute respiratory failure, pneumonia, acute respiratory distress syndrome (ARDS), febrile seizures and encephalitis/encephalopathy. The percentage of hospitalizations by age was 2.96% of patients aged 0-1 years; 0.77% aged 2-5; 0.51% aged 6-12; 0.78% aged 13-18; 1.36% aged 19-44; 1.19% aged 45-64; and 2.21% aged 65-74. The incidence of hospitalizations from these five complications combined was highest in patients aged 0-1 years (94.3 per 10000) compared with 30.7 in those aged 2-5 years and 27.1 in those aged 65-74 years. For pneumonia, incidence was highest for patients aged 0-5 years and 65 years or more. There were statistically significant decreasing trends over the years in the incidence of hospitalizations from pneumonia and febrile seizures.
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