| Project/Area Number |
15K08787
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大西 志保 鈴鹿医療科学大学, 薬学部, 助教 (80511914)
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| Co-Investigator(Renkei-kenkyūsha) |
MA Ning 鈴鹿医療科学大学, 医療科学研究科, 教授 (30263015)
TABATA Tsutomu 三重大学, 医学研究科, 准教授 (40252358)
IIJIMA Katsunori 秋田大学, 医学研究科, 教授 (60375003)
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| Research Collaborator |
MURATA Mariko 三重大学大学院, 医学研究科, 教授 (10171141)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | がん予防 / 炎症 / DNA損傷 |
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| Outline of Final Research Achievements |
Chronic infection and inflammation have been recognized as important factors for carcinogenesis. Inflammation is estimated to contribute to approximately 25 % of human cancers. It is urgent problem to be solved, the risk assessment in early phase and prevention of inflammation-related carcinogenesis. We have reported that 8-nitroguanine, nitrative DNA damage specifically generated under inflammation, is generated in cancerous site before carcinogenesis. Therefore, 8-nitroguanine is hopeful marker for risk assessment of inflammation-related carcinogenesis. However, it is difficult to analyze 8-nitroguanine with quantitativity and minimal-invasiveness. In this study, we successed to confirm the amount of 8-nitroguanine quantitatively with using high performance liquid chromatography coupled with an electrochemical detector (HPLC-ECD).
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