| Project/Area Number |
15K08791
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Hokkaido Institute of Public Health |
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Principal Investigator |
Kojima Hiroyuki 北海道立衛生研究所, 生活科学部, 部長 (10414286)
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 智宏 北海道立衛生研究所, その他部局等, 主査 (10414327)
室本 竜太 北海道大学, 薬学研究院, 講師 (30455597)
浦丸 直人 日本薬科大学, 薬学部, 講師 (90424069)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEUCHI Shinji 北海道立衛生研究所, 生活科学部, 主査 (20414287)
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| Research Collaborator |
SUGANO Youhei
OKUDA Katsuhiro
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 化学物質 / 免疫毒性 / 核内受容体 / 複合曝露影響 / 環境化学物質 / 遺伝子発現 / 免疫 / 複合曝露 / ポリ塩化ビフェニル類 / ビスフェノール類 / 難燃剤 / 可塑剤 / 環境 |
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| Outline of Final Research Achievements |
We examined the effects of chemicals contained in foods on transcriptional activity via human nuclear receptors, and the effects of these compounds on global gene expression in immune cells. As a result, we revealed that bisphenol A and its analogs, phthalates, organophosphate flame retardants, PCBs and perfluoroalkyl acids have agonistic and/or antagonistic activity against nuclear receptors in in vitro reporter gene assays. In addition, these compounds were found to act as inducers and depressors of gene expression in human macrophage-like THP-1 cells using microarray analysis. Taken together, these results suggest that such chemical mixtures might affect the gene expression of THP-1 cells via nuclear receptors.
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