Effects of chemical mixtures contained in foods on immune response via nuclear receptors.
| Project/Area Number |
15K08791
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Hokkaido Institute of Public Health |
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Principal Investigator |
Kojima Hiroyuki 北海道立衛生研究所, 生活科学部, 部長 (10414286)
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 智宏 北海道立衛生研究所, その他部局等, 主査 (10414327)
室本 竜太 北海道大学, 薬学研究院, 講師 (30455597)
浦丸 直人 日本薬科大学, 薬学部, 講師 (90424069)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEUCHI Shinji 北海道立衛生研究所, 生活科学部, 主査 (20414287)
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| Research Collaborator |
SUGANO Youhei
OKUDA Katsuhiro
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 化学物質 / 免疫毒性 / 核内受容体 / 複合曝露影響 / 環境化学物質 / 遺伝子発現 / 免疫 / 複合曝露 / ポリ塩化ビフェニル類 / ビスフェノール類 / 難燃剤 / 可塑剤 / 環境 |
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| Outline of Final Research Achievements |
We examined the effects of chemicals contained in foods on transcriptional activity via human nuclear receptors, and the effects of these compounds on global gene expression in immune cells. As a result, we revealed that bisphenol A and its analogs, phthalates, organophosphate flame retardants, PCBs and perfluoroalkyl acids have agonistic and/or antagonistic activity against nuclear receptors in in vitro reporter gene assays. In addition, these compounds were found to act as inducers and depressors of gene expression in human macrophage-like THP-1 cells using microarray analysis. Taken together, these results suggest that such chemical mixtures might affect the gene expression of THP-1 cells via nuclear receptors.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.2017
Author(s)
Abe, T., Takahashi, M., Kano, M., Amaike, Y., Ishii, C., Maeda, K., Kudoh, Y., Morishita, T., Hosaka, T., Sasaki, T., Kodama, S., Matsuzawa, A., Kojima, H., Yoshinari, K.
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Journal Title
Arch. Toxicol.
Volume: 印刷中
Issue: 6
Pages: 2365-2374
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities2016
Author(s)
Chieri Fujino, Yuki Tamura, Satoko Tange, Hiroyuki Nakajima, Seigo Sanoh, Yoko Watanabe, Naoto Uramaru, Hiroyuki Kojima, Kouichi Yoshinari, Shigeru Ohta, Shigeyuki Kitamura
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Journal Title
The Journal of Toxicological Sciences
Volume: 41
Issue: 5
Pages: 677-691
DOI
NAID
ISSN
0388-1350, 1880-3989
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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