Identification of Scientific evidence for Traditional Kampo theory by gene expression analysis

• Project/Area Number: 15K08902
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: University of Toyama
• Principal Investigator: Saiki Ikuo 富山大学, 和漢医薬学総合研究所, 研究員 (80133776)
• Co-Investigator(Kenkyū-buntansha): 横山 悟 富山大学, 和漢医薬学総合研究所, 助教 (90613498)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 漢方薬 / 生薬 / 漢方理論 / 構成生薬 / 生薬由来化合物 / 遺伝子発現

Outline of Final Research Achievements

Kampo medicine has not enough scientific evidences yet. To identify the evidences of Kampo theory, we focused on the herbal medicines, which are contained in Kampo medicines.
We determined that the crude drugs/herbs belonging to the same category in traditional Kampo theory share a common effect on intracellular signaling activity in vitro.

Research Products

• [Journal Article] NK Cells Control Tumor-Promoting Function of Neutrophils in Mice (2018)
  • Author(s): Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y
  • Journal Title: Cancer Immunol Res Volume: 印刷中 Issue: 3 Pages: 348-357
  • DOI: 10.1158/2326-6066.cir-17-0204
  • NAID: 120006402039
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma (2017)
  • Author(s): Xu Xiaoou、Yokoyama Satoru、Hayakawa Yoshihiro、Saiki Ikuo
  • Journal Title: Oncology Reports Volume: 38 Issue: 1 Pages: 538-544
  • DOI: 10.3892/or.2017.5672
  • Peer Reviewed
• [Journal Article] Ethanolic extract of Thevetia peruviana flowers enhances TNF-α and TRAIL-induced apoptosis of human cervical cancer cells via intrinsic and extrinsic pathways (2017)
  • Author(s): Managit Chittima、Sakurai Hiroaki、Saiki Ikuo
  • Journal Title: Oncology Letters Volume: 13 Issue: 4 Pages: 2791-2798
  • DOI: 10.3892/ol.2017.5748
  • Peer Reviewed
• [Journal Article] Highly oxygenated antiausterity agents from the leaves of Uvaria dac. (2017)
  • Author(s): Awale S, Tawila AM, Dibwe DF, Ueda JY, Sun S, Athikomkulchai S, Balachandran C, Saiki I, Matsumoto K, Esumi H.
  • Journal Title: Bioorg Med Chem Lett. Volume: 27 Issue: 9 Pages: 1967-1967
  • DOI: 10.1016/j.bmcl.2017.03.021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chemosensitizing Effect of Saikosaponin B on B16F10 Melanoma Cells. (2017)
  • Author(s): Ma H, Yokoyama S, Saiki I, Hayakawa Y.
  • Journal Title: Nutr Cancer. Volume: 69 Issue: 3 Pages: 505-511
  • DOI: 10.1080/01635581.2017.1285407
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p38 pathway as a key downstream signal of connective tissue growth factor to regulate metastatic potential in non-small-cell lung cancer. (2016)
  • Author(s): Kato S., Yokoyama S., Hayakawa Y., Luhui L., Iwakami Y., Sakurai H., and Saiki I.
  • Journal Title: Cancer Science Volume: 107 Issue: 10 Pages: 1416-1421
  • DOI: 10.1111/cas.13009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] AKT-STAT3 Pathway as a Downstream Target of EGFR Signaling to Regulate PD-L1 Expression on NSCLC cells. (2016)
  • Author(s): Abdelhamed S, Ogura K, Yokoyama S, Saiki I, Hayakawa Y.
  • Journal Title: J Cancer. Volume: 7 Pages: 1579-1586
  • Peer Reviewed
• [Journal Article] IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression. (2016)
  • Author(s): Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.
  • Journal Title: Cancer Sci. Volume: 107 Issue: 9 Pages: 1206-14
  • DOI: 10.1111/cas.13005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficient use of a crude drug/herb library reveals Ephedra Herb as a specific antagonist for Th2-specific chemokine receptors CCR3, CCR4, and CCR8 (2016)
  • Author(s): Matsuo K, Koizumi K, Fujita M, Morikawa T, Jo M, Shibahara N, Saiki I, Yoshie O, Nakayama T
  • Journal Title: Front. Cell Dev. Biol. Volume: 4 Pages: 54-54
  • DOI: 10.3389/fcell.2016.00054
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells. (2016)
  • Author(s): Lou C, Yokoyama S, Abdelhamed S, Saiki I, Hayakawa Y.
  • Journal Title: Oncol Lett. Volume: 12 Pages: 295-300
  • Peer Reviewed
• [Journal Article] Helicobacter pylori induces serine phosphorylation of EGFR via novel TAK1-p38 activation pathway in an HB-EGF-independent manner. (2015)
  • Author(s): Zaidi S.F., Refaat A., Zhou Y., Muhammad J.S., Shin M.S., Saiki I., Sakurai H., and Sugiyama T.
  • Journal Title: Helicobacter Volume: 印刷中 Issue: 5 Pages: 381-389
  • DOI: 10.1111/hel.12215
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Anti-inflammatory Effect of Cinnamaldehyde in <i>Helicobacter pylori</i> Induced Gastric Inflammation (2015)
  • Author(s): Muhammad JS, Zaidi SF, Shaharyar S, Refaat A, Usmanghani K, Saiki I, Sugiyama T.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 38 Issue: 1 Pages: 109-115
  • DOI: 10.1248/bpb.b14-00609
  • NAID: 130004872218
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Effect of keishibukuryogan on genetic and dietary obesity models. (2015)
  • Author(s): Gao F, Yokoyama S, Fujimoto M, Tsuneyama K, Saiki I, Shimada Y, Hayakawa Y.
  • Journal Title: Evid Based Complement Alternat Med. Volume: in press Pages: 801291-801298
  • DOI: 10.1155/2015/801291
  • NAID: 120006389608
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation. (2015)
  • Author(s): Takahashi K, Nagai N, Ogura K, Tsuneyama K, Saiki I, Irimura T, Hayakawa Y.
  • Journal Title: Cancer Sci. Volume: 106 Issue: 7 Pages: 867-874
  • DOI: 10.1111/cas.12685
  • NAID: 120006389612
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments. (2015)
  • Author(s): Wada A, Ito A, Iitsuka H, Tsuneyama K, Miyazono T, Murakami J, Shibahara N, Sakurai H, Saiki I, Nakayama T, Yoshie O, Koizumi K, Sugiyama T.
  • Journal Title: Oncol Rep. Volume: 33 Issue: 6 Pages: 2935-2939
  • DOI: 10.3892/or.2015.3941
  • Peer Reviewed
• [Journal Article] Multi-pathway cellular analysis on crude natural drugs/herbs from Japanese Kampo formulations. (2015)
  • Author(s): Eshima S, Yokoyama S, Abe T, Hayakawa Y, Saiki I.
  • Journal Title: PLoS One Volume: 10 Issue: 6 Pages: e0128872-e0128872
  • DOI: 10.1371/journal.pone.0128872
  • NAID: 120006389615
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2. (2015)
  • Author(s): Zhou Y, Yamada N, Tanaka T, Hori T, Yokoyama S, Hayakawa Y, Yano S, Fukuoka J, Koizumi K, Saiki I, Sakurai H.
  • Journal Title: Nat Commun. Volume: 6 Issue: 1 Pages: 7679-7679
  • DOI: 10.1038/ncomms8679
  • NAID: 120006986997
  • Peer Reviewed / Open Access
• [Journal Article] Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model. (2015)
  • Author(s): Takeno N, Inujima A, Shinohara K, Yamada M, Shibahara N, Sakurai H, Saiki I, Koizumi K.
  • Journal Title: Int J Oncol. Volume: 47 Issue: 6 Pages: 2115-2122
  • DOI: 10.3892/ijo.2015.3208
  • Peer Reviewed
• [Journal Article] Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy. (2015)
  • Author(s): Refaat A, Abdelhamed S, Saiki I, Sakurai H.
  • Journal Title: Oncol Lett. Volume: 10 Pages: 1907-1911
  • Peer Reviewed
• [Journal Article] Lead compound bearing caffeic scaffold induces EGFR suppression in solid tumor cancer cells. (2015)
  • Author(s): Mudjupa C., Abdelhamed S., Refaat A., Yokoyama S., Saiki I. and Vajragupta O.
  • Journal Title: J. Applied Biomed. Volume: 13 Pages: 305-317
  • Peer Reviewed
• [Journal Article] An herbal plant derived compound, 1,2,3,4,6-penta-O-galloyl-β-D- glucose (PGG), increases cross-presentation of antigens to MHC class I molecules in dendritic cells. (2015)
  • Author(s): Inujima A., Yamada M., Takeno N., Hoshina A., Oe M., Shinohara M., Shibahara N., Sakurai H., Saiki I. and Koizumi K.
  • Journal Title: Trad. Kampo Med. Volume: 2 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer (2015)
  • Author(s): Toge M, Yokoyama S, Kato S, Sakurai H, Senda K, Doki Y, Hayakawa Y, Yoshimura N, Saiki I
  • Journal Title: Int. J. Oncol. Volume: 46 Issue: 4 Pages: 1844-1848
  • DOI: 10.3892/ijo.2015.2861
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Selective anticancer activity of hirsutine against HER2‑positive breast cancer cells by inducing DNA damage. (2015)
  • Author(s): Lou C, Yokoyama S, Saiki I, Hayakawa Y.
  • Journal Title: Oncol Rep. Volume: 33 Issue: 4 Pages: 2072-2076
  • DOI: 10.3892/or.2015.3796
  • Peer Reviewed
• [Journal Article] TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo. (2015)
  • Author(s): Xue R, Han N, Xia M, Ye C, Hao Z, Wang L, Wang Y, Yang J, Saiki I, Yin J.
  • Journal Title: Steroids Volume: 94 Pages: 51-59
  • DOI: 10.1016/j.steroids.2014.12.015
  • Peer Reviewed
• [Journal Article] Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation. (2014)
  • Author(s): Kee JY, Inujima A, Andoh T, Tanaka K, Li F, Kuraishi Y, Sakurai H, Shibahara N, Saiki I, Koizumi K.
  • Journal Title: J Nat Med. Volume: 69 Issue: 2 Pages: 209-217
  • DOI: 10.1007/s11418-014-0880-6
  • Peer Reviewed
• [Presentation] Herbal medicines regulate HTLV-I provirus activation (2017)
  • Author(s): Fujii H., Hayakawa Y., Takahashi Y., Tanaka R., Saiki I., Fukushima T. and Tanaka Y.
  • Organizer: 18th International Conference on Human Retrovirology HTLV and related Viruses
  • Place of Presentation: 東京
  • Year and Date: 2017-03-07
• [Presentation] COP9シグナロソーム5(COPS5)は転写因子SNAILを脱ユビキチン化することにより肺がんの転移を制御する (2017)
  • Author(s): 横山悟, 早川芳弘, 櫻井宏明, 済木育夫
  • Organizer: 第2１回日本がん分子標的治療学会
• [Presentation] メラノーマにおける脱ユビキチン化酵素PSMD14の細胞増殖および転移に対する効果の検討 (2017)
  • Author(s): 岩上雄亮, 横山悟, 早川芳弘, 済木育夫
  • Organizer: 第26回日本がん転移学会
• [Presentation] NK cells control tumor-promoting function of neutrophils. (2017)
  • Author(s): Ogura K, Sato-Matsushita M, Hori T, Iwakura Y, Tahara H, Saiki I, Hayakawa Y.
  • Organizer: The 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS2017)
  • Int'l Joint Research
• [Presentation] Immunomodulatory DrugsのNK細胞を介したがん転移抑制機序の解明 (2017)
  • Author(s): 宮里紀穂, 済木育夫, 早川芳弘
  • Organizer: 第26回日本がん転移学術集会
• [Presentation] オウレンはBAX / BAKの活性化によるアポトーミスを誘導し，悪性黒色腫の成長を阻害する (2017)
  • Author(s): 徐小鴎, 横山悟, 早川芳弘, 済木育夫
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 漢方薬とがん転移 (2017)
  • Author(s): 済木育夫
  • Organizer: 日本東洋医学会 関東甲信越支部 平成28 年度千葉県部会
  • Place of Presentation: 千葉
  • Invited
• [Presentation] Berberine and Cancer Metastasis, (2016)
  • Author(s): Saiki I.:
  • Organizer: The 3rd International Conference on Pharma and Food
  • Place of Presentation: 静岡
  • Year and Date: 2016-11-16
  • Invited
• [Presentation] 自然リンパ球をターゲッ トとしたがん関連炎症制御 (2016)
  • Author(s): 早川芳弘, 小倉圭介, 松下まりも, 入村達郎, 田原秀晃, 済木育夫
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
  • Int'l Joint Research
• [Presentation] Coptidis Rhizoma shows a potential Slug targeted strategy in melanoma metastasis. (2016)
  • Author(s): Xu X., Yokoyama S., Hayakawa Y. and Saiki I.
  • Organizer: The 16th International Biennial Congress of the Metastasis Research Sciety
  • Place of Presentation: China
  • Year and Date: 2016-09-16
  • Int'l Joint Research
• [Presentation] Crucial roles of RSK in cell motility by catalyzing Ser-897 phosphorylation of EphA2 (2016)
  • Author(s): Zhou Y., Yamada N., Tanaka T., Hori T., Yokoyama S., Hayakawa Y., Yano S., Fukuoka J., Koizumi K., Saiki I. and Sakurai H.
  • Organizer: The 16th International Biennial Congress of the Metastasis Research Sciety
  • Place of Presentation: China
  • Year and Date: 2016-09-16
  • Int'l Joint Research
• [Presentation] メラノーマの転移抑制を目指した転写因 子SLUG に対する脱ユビキチン化酵素の探索 (2016)
  • Author(s): 岩上 雄亮, 横山 悟, 早川 芳弘, 済木 育夫
  • Organizer: 平成28 年度新学術領域研究「学術研究支 援基盤形成【先端モデル動物支援プラットフォーム】若手支援技術講習会」
  • Place of Presentation: 長野
  • Year and Date: 2016-09-15
• [Presentation] Berberine in Coptidis rhizoma inhibits cancer metastasis (2016)
  • Author(s): Saiki I.
  • Organizer: The International Seminar on Pharmacology and Clinical Pharmacy 2016
  • Place of Presentation: Indonesia
  • Year and Date: 2016-09-01
  • Int'l Joint Research / Invited
• [Presentation] 没薬による免疫チェックポイント分子PD-L1 の発現抑制 (2016)
  • Author(s): 横山 悟, 早川芳弘, 済木育夫
  • Organizer: 第33 回和漢医薬学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-08-27
• [Presentation] 生薬によるHTLV-I プロウイルス活性 化制御 (2016)
  • Author(s): 藤猪英樹, 早川芳弘, 高橋良明, 済木育夫, 田中勇悦
  • Organizer: 第3 回日本HTLV-1 学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2016-08-26
• [Presentation] 炎症性微小環境制御を介したナチ ュラルキラー細胞による新規がん細胞増殖制御機構の解明 (2016)
  • Author(s): 小倉圭介, 松下まりも, 田原秀晃, 済木育夫, 早川芳弘
  • Organizer: 第20 回日本がん免疫学会総 会
  • Place of Presentation: 大阪
  • Year and Date: 2016-07-27
• [Presentation] B16F10 メランーマ 浸潤リンパ球の単一細胞解析による、がん特異的T 細胞の同定およびTCR 遺伝子治療の 試み (2016)
  • Author(s): 下岡清美, 浜名 洋, 呂 福蓮, 小澤龍彦, 早川芳弘, 岸 裕幸, 村口 篤
  • Organizer: 第20 回日本がん免疫学会総 会
  • Place of Presentation: 大阪
  • Year and Date: 2016-07-27
• [Presentation] IL-17A-producing CD30+ Vδ1 T cells drive inflammation-induced cancer progression. (2016)
  • Author(s): Hayakawa Y., Kimura Y., Nagai N., Saiki I. and Irimura T.
  • Organizer: MMCB 2016, The 24th International Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: 東京
  • Year and Date: 2016-06-04
  • Int'l Joint Research
• [Presentation] 「がんと漢方」, 漢方薬によるがん転移の抑制, (2016)
  • Author(s): 済木育夫
  • Organizer: 第67 回日本東 洋医学会総会
  • Place of Presentation: 高松
  • Year and Date: 2016-06-03
  • Invited
• [Presentation] Berberine, in Coptidis rhizoma and Phellodendri cortex, inhibits cancer metastasis. (2016)
  • Author(s): Saiki I.
  • Organizer: “Pharmaceutical Research for Local Needs and International Collaborations”, 32nd International Annual Meeting in Pharmaceutical Sciences (Chulalongkorn University),
  • Place of Presentation: Thailand
  • Year and Date: 2016-03-10
  • Invited
• [Presentation] Vδ１T細胞を起点とする炎症によるがん進展メカニズム解析 (2016)
  • Author(s): 早川芳弘, 木村好孝, 永井直, 善本隆之, 岡田太, 田原秀晃, 濟木育夫
  • Organizer: 平成27年度「個体レベルでのがん研究支援活動」ワークショップ
  • Place of Presentation: 滋賀
  • Year and Date: 2016-02-03
• [Presentation] 炎症性微小境制御を介したナチュラルキラー細胞による新規がん細胞増殖抑制機構の解明 (2016)
  • Author(s): 小倉圭介, 松下まりも, 田原秀晃, 済木育夫, 早川芳弘
  • Organizer: 平成27年度「個体レベルでのがん研究支援活動」ワークショップ
  • Place of Presentation: 滋賀
  • Year and Date: 2016-02-03
• [Presentation] Immunomodulatory Drugs(IMiDs)の自然免疫応答を介したがん転移抑制機序の解明 (2016)
  • Author(s): 宮里紀穂, 済木育夫, 田原秀晃, 早川芳弘
  • Organizer: 平成27年度「個体レベルでのがん研究支援活動」ワークショップ
  • Place of Presentation: 滋賀
  • Year and Date: 2016-02-03
• [Presentation] In vivo anti-metastatic effect of ginseng saponins and their intestinal bacterial metabolites after oral administration and their molecular mechanism for the inhibition of metastasis (2016)
  • Author(s): Saiki I.
  • Organizer: “Collaborative Research Meeting”
  • Place of Presentation: Thailand
  • Year and Date: 2016-01-25
  • Invited
• [Presentation] Inhibition of berberine on cancer metastasis. (2016)
  • Author(s): Saiki I.
  • Organizer: Science Seminar in Military Institute of Traditional Medicinal (MITM) ~New Achivements in medicinal materiall research~
  • Place of Presentation: Hanoi, Vietnam
  • Int'l Joint Research / Invited
• [Presentation] Inhibition of berberine on cancer metastasis (2016)
  • Author(s): Saiki I.
  • Organizer: Science Conference in Celebration of National Institute of Medicinal Materials (NIMM) 55th Anniversary
  • Place of Presentation: Hanoi, Vietnam
  • Int'l Joint Research / Invited
• [Presentation] がんと漢方薬 (2016)
  • Author(s): 済木育夫
  • Organizer: 第23 回日本東洋医学会北陸支部夏季講演会
  • Place of Presentation: 金沢
  • Invited
• [Presentation] がん関連炎症制御におけるナチュラルキラー細胞の役割解明 (2015)
  • Author(s): 小倉圭介，佐藤（松下）まりも，田原秀晃，済木育夫，早川芳弘
  • Organizer: The 74th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 肺がんの転移抑制を目指した転写因子SNAILの脱ユビキチン化酵素の探索 (2015)
  • Author(s): 渡辺謙介，横山悟，兼頭直希，加藤真一郎，早川芳弘，済木育夫
  • Organizer: The 74th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] RSKを介したEphA2 Ser-897リン酸化による細胞運動の制御機構 (2015)
  • Author(s): 周越，山田直樹，田中智大，堀隆，横山悟，早川芳弘，矢野聖二，福岡順也，小泉桂一，済木育夫，櫻井宏明
  • Organizer: The 74th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 細胞内シグナルに対する生薬・漢方方剤の効果 (2015)
  • Author(s): 横山悟，江島静，阿部貴志，早川芳弘，済木育夫
  • Organizer: 第14回日本臨床中医薬学会学術大会
  • Place of Presentation: 富山
  • Year and Date: 2015-09-29
• [Presentation] 十全大補湯のワクチンアジュバントとしての応用 (2015)
  • Author(s): 小泉桂一，後藤博三，済木育夫
  • Organizer: 第14回日本臨床中医薬学会学術大会
  • Place of Presentation: 富山
  • Year and Date: 2015-09-29
• [Presentation] 特別講演I・市民公開講座「がんと漢方薬」 (2015)
  • Author(s): 済木育夫
  • Organizer: 日本生薬学会第62回年会
  • Place of Presentation: 岐阜
  • Year and Date: 2015-09-11
• [Presentation] 細胞内シグナルに及ぼす効果による生薬分類 (2015)
  • Author(s): 横山悟，江島静，阿部貴志，早川芳弘，済木育夫
  • Organizer: 第32回和漢医薬学会総会
  • Place of Presentation: 富山
  • Year and Date: 2015-08-22
• [Presentation] 凍結技法による肺転移癌組織における血行動態とHIF-1a発現の可視化解析法 (2015)
  • Author(s): 齊藤百合花，大野伸彦，済木育夫，大野伸一
  • Organizer: 第24回日本がん転移学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-23
• [Presentation] メラノーマの転移抑制を目指した転写因子SLUGに対する脱ユビキチン化酵素の探索 (2015)
  • Author(s): 岩上雄亮，横山悟，早川芳弘，済木育夫
  • Organizer: 第24回日本がん転移学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-23
• [Presentation] ケモカインCX3CL1を介した多発性骨髄腫細胞の悪性化機序 (2015)
  • Author(s): 小泉桂一，櫻井宏明，済木育夫
  • Organizer: 第24回日本がん転移学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-23
• [Presentation] がん悪性化進展を促す炎症性免疫応答の維持機構におけるIL-17の重要性 (2015)
  • Author(s): 早川芳弘，永井直，済木育夫，入村達郎
  • Organizer: 第24回日本がん転移学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-23
• [Presentation] Mammary tissue microenviroment determines T cell-dependent breast cancer-saaciated infamymation. (2015)
  • Author(s): Takahashi K., Irimura T., Saiki I. and Hayakawa Y.
  • Organizer: International Conference of cancer immuneotherapy and Macrophages 2015
  • Place of Presentation: 東京
  • Year and Date: 2015-07-09
• [Presentation] 「漢方薬とがん転移 ～基礎からの提言～」 (2015)
  • Author(s): 済木育夫
  • Organizer: 第66回日本東洋医学会総会
  • Place of Presentation: 富山
  • Year and Date: 2015-06-12
  • Invited
• [Presentation] Vδ1 T細胞を起点とする炎症によるがん悪性化メカニズムの理解と治療への応用 (2015)
  • Author(s): 早川芳弘，入村達郎，済木育夫
  • Organizer: 第19回日本がん分子標的治療学会
  • Place of Presentation: 松山
  • Year and Date: 2015-06-10
• [Presentation] BAX/BAKに着目した悪性黒色腫に対する新規薬剤併用法の探索 (2015)
  • Author(s): 横山悟，早川芳弘，済木育夫
  • Organizer: 第19回日本がん分子標的治療学会
  • Place of Presentation: 松山
  • Year and Date: 2015-06-10
• [Presentation] EphA2チロシンキナーゼ型受容体のセリンリン酸化による細胞運動能制御 (2015)
  • Author(s): 櫻井宏明，小泉桂一，済木育夫
  • Organizer: 第19回日本がん分子標的治療学会
  • Place of Presentation: 松山
  • Year and Date: 2015-06-10
• [Remarks] 富山大学 和漢医薬学総合研究所 病態生化学分野
  • URL: http://www.inm.u-toyama.ac.jp/pb/index-j.html
• [Remarks] 富山大学 和漢医薬学総合研究所 病態生化学分野 研究業績
  • URL: http://www.inm.u-toyama.ac.jp/pb/gyoseki/index.html