• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A randomized acupuncture trial on non-specific neck/shoulder stiffness to investigate placebo and nocebo effects lurking in blind study

Research Project

Project/Area Number 15K08938
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionTokyo Ariake University of Medical and Health Sciences

Principal Investigator

Takayama Miho  東京有明医療大学, 保健医療学部, 講師 (20563414)

Co-Investigator(Kenkyū-buntansha) 矢嶌 裕義  東京有明医療大学, 保健医療学部, 准教授 (00563412)
高倉 伸有  東京有明医療大学, 保健医療学部, 教授 (60563400)
Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords鍼 / プラセボ / ダブルブラインド / 肩こり / 補完代替医療 / ノセボ効果
Outline of Final Research Achievements

It is difficult to obtain a specific efficacy of acupuncture treatments with needle penetration in clinical trials since acupuncture has a large impact to patients to induce placebo effect that is the improvement induced by patients' positive perception of the treatment. In this study, we applied double-blind real or sham needles we developed to find a specific efficacy of acupuncture to neck/shoulder stiffness patients who were told "A treatment you will receive is effective" or "A treatment you will receive is ineffective." We found the neck/shoulder stiffness in real and sham groups were similarly improved and significant decrease of improvement in patients who were told the treatment they will receive is ineffective.
The results suggest the truth of the effectiveness of acupuncture and the significance of the patient's positive perception of the treatment in it. Further studies are necessary to evaluate usefulness of acupuncture for patients' benefit in daily life.

Academic Significance and Societal Importance of the Research Achievements

従来の鍼の臨床研究では、治療にあたるはり師が、その治療が本物か偽物かを知って治療していたため、患者様がその治療者の影響を受けて治療効果を判定する可能性があった。しかし本研究では、そのような治療者の影響がない特別な鍼を用いることにより、患者様に治療効果をより正しく評価してもらうことができた。その結果、患者様が鍼の刺激感や治療効果に関する事前情報を肯定的に受け止めることが、治療をより効果的なものにする可能性を示すことができた。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (38 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (7 results) Journal Article (12 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 12 results,  Open Access: 7 results) Presentation (19 results) (of which Int'l Joint Research: 4 results)

  • [Int'l Joint Research] University of Illinois at Chicago/Beth Israel Deaconess Medical Center/Harvard Medical School(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Illinois at Chicago/Beth Israel Deaconess Medical Center/Harvard Medical School(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Illinois at Chicago/Martinos center for Biomedical Imaging/Beth Israel Deaconess Medical Center(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] The University of Illinois at Chicago(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Martinos Center for Biomedical Imaging(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Beth Israel Deaconess Medical Center(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University of Illinois at Chicago(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Acupuncture- And Intermittent Compression-Induced Changes in Blood Circulation of Tendon2020

    • Author(s)
      Kubo K, Iizuka Y, Yajima H, Takayama M, Takakura N.
    • Journal Title

      J Altern Complement Med.

      Volume: 26(3) Issue: 3 Pages: 231-238

    • DOI

      10.1089/acm.2019.0345

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acupuncture to Improve Symptoms for Stable Angina: Protocol for a Randomized Controlled Trial2019

    • Author(s)
      Schlaeger J, Cai HY, Steffen AD, Angulo V, Shroff AR, Briller JE, Hoppensteadt D, Uwizeye G, Pauls HA, Takayama M, Yajima H, Takakura N, DeVon HA.
    • Journal Title

      JMIR Res Protoc

      Volume: 8(7) Issue: 7 Pages: e14705-e14705

    • DOI

      10.2196/14705

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A double-blind study on acupuncture sensations with Japanese style of acupuncture: comparison between penetrating and placebo needles.2018

    • Author(s)
      Nishiwaki M, Takayama M, Yajima H, Nasu M, Park J, Kong J, Takakura N.
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: 8128147 Issue: 1 Pages: 11-11

    • DOI

      10.1155/2018/8128147

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Patient blinding with blunt tip of placebo acupuncture needles: comparison between 1 mm and 2 mm skin press.2018

    • Author(s)
      Takakura N, Takayama M, Nasu M, Nishiwaki M, Kawase A, Yajima H.
    • Journal Title

      Journal of Integrative Medicine

      Volume: 16(3) Pages: 164-171

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blinding indices and blinding scenarios of practitioners and patients with acupuncture needles for double blinding.2018

    • Author(s)
      Takakura N, Takayama M, Nishiwaki M, Yajima H.
    • Journal Title

      Acupunct Med

      Volume: 36(2) Issue: 2 Pages: 123-124

    • DOI

      10.1136/acupmed-2017-011430

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Double-blind and single-blind retractable placebo needles.2018

    • Author(s)
      Takakura N, Takayama M, Yajima H.
    • Journal Title

      Anaesthesia

      Volume: 73(2) Issue: 2 Pages: 258-260

    • DOI

      10.1111/anae.14208

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Japanese version of the Massachusetts General Hospital Acupuncture Sensation Scale: A validation study.2017

    • Author(s)
      Nishiwaki M, Takayama M, Yajima H, Nasu M, Kong J, Takakura N.
    • Journal Title

      Evid Based Complement Alternat Med

      Volume: 2017 Issue: 1 Pages: 7093967-7093967

    • DOI

      10.1155/2017/7093967

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Japanese version of the Massachusetts General Hospital Acupuncture Sensation Scale: A validation study2017

    • Author(s)
      Masako Nishiwaki, Miho Takayama, Hiroyoshi Yajima, Morihiro Nasu, Jian Kong, Nobuari Takakura
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: In Press

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acupuncture for Menopausal Hot Flashes2016

    • Author(s)
      Nobuari Takakura, Miho Takayama, Hiroyoshi Yajima
    • Journal Title

      Annals of Internal Medicine

      Volume: 165(6) Issue: 6 Pages: 448-449

    • DOI

      10.7326/l16-0200

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acupuncture and Acupressure in Labor2016

    • Author(s)
      Judith M. Schlaeger, Elizabeth M. Gabzdyl, Jeanie L. Bussell, Nobuari Takakura, Hiroyoshi Yajima, Miho Takayama, Diana J.Wilkie
    • Journal Title

      Journal of Midwifery &Women’s Health

      Volume: 62(1) Issue: 1 Pages: 12-28

    • DOI

      10.1111/jmwh.12545

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Is skin-touch sham needle not placebo? A double-blind crossover study on pain alleviation.2015

    • Author(s)
      Takayama M, Yajima H, Kawase A, Homma I, Izumizaki M, Takakura N.
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: 2015 Pages: 152086-152086

    • DOI

      10.1155/2015/152086

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The difference of Park and Streitberger single-blind needles from Takakura double-blind needle.2015

    • Author(s)
      Takakura N, Takayama M, Yajima H.
    • Journal Title

      Journal of Integrative Medicine

      Volume: 13 Issue: 4 Pages: 212-214

    • DOI

      10.1016/s2095-4964(15)60189-3

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 東京有明医療大学附属鍼灸センターの受療患者像 (第2報) 受療の契機となった情報の分析2019

    • Author(s)
      水出 靖, 木村 友昭, Chuluunbat Oyunchimeg , 高梨 知揚, 藤本 英樹, 菅原 正秋, 高山 美歩, 谷口 博志, 矢嶌 裕義, 古賀 義久, 安野 富美子, 坂井 友実
    • Organizer
      第68回(公社)全日本鍼灸学会学術大会(名古屋)
    • Related Report
      2019 Annual Research Report
  • [Presentation] eスポーツアスリートが抱える愁訴に対する鍼治療の試み プロゲーミングチームにおける活動報告2019

    • Author(s)
      平松耀, 高梨知揚, 矢嶌裕義, 高山美歩, 納部瑠夏, 川瀬明子, Sclaeger Judith, 高倉伸有
    • Organizer
      第68回(公社)全日本鍼灸学会学術大会(名古屋)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 安全鍼および今井式クリーンニードルの安全性の検証 第2報 細菌汚染押手によるリスクについて2019

    • Author(s)
      菅原正秋, 高山美歩, 矢嶌裕義, 高倉伸有
    • Organizer
      第68回(公社)全日本鍼灸学会学術大会(名古屋)
    • Related Report
      2019 Annual Research Report
  • [Presentation] The usefulness of acupuncture to the eSport athletes2019

    • Author(s)
      You HIRAMATSU, Tomoaki TAKANASHI, Hiroyoshi YAJIMA, Miho TAKAYAMA, Crystal L. PATIL, Judith M. SCHLAEGER, Nobuari TAKAKURA
    • Organizer
      2019 DiGRA JAPAN Summer Conference Program
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脳出血後に生じた肩関節痛と運動制限に対する鍼治療の効果-表面筋電図による肩周囲筋活動の評価の有用性を示す症状-2019

    • Author(s)
      納部瑠夏, 奈須守洋, 平松燿, 内田裕, 田中智大, 喜多村崇, 荒木美紗江, 川上桃子, 高山美歩, 高倉伸有, 矢嶌裕義
    • Organizer
      日本鍼灸学会関東支部学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 鍼治療が膝蓋腱血液量に及ぼす影響ーダブルブラインド用鍼を用いて2019

    • Author(s)
      飯塚洋二朗、矢嶌裕義、高山美歩、高倉伸有、久保啓太郎
    • Organizer
      第74回日本体力医学会(茨城)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 鍼感覚質問紙(日本語版MASS)を用いた鍼感覚の検討(第2報) -圧迫深度による鍼感覚の違い-2018

    • Author(s)
      西脇政子、矢嶌裕義、高山美歩、奈須守洋、大渕修哉、川瀬明子、平川稚佳子、高倉伸有
    • Organizer
      第67回全日本鍼灸学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 下顎部の痛みに対する鍼の効果に関する基礎的研究 -ダブルブラインド用鍼を用いて-2018

    • Author(s)
      大渕修哉、高山美歩、西脇政子、奈須守洋、川瀬明子、平川稚佳子、矢嶌裕義、高倉伸有
    • Organizer
      第67回全日本鍼灸学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 安全鍼および今井式クリーンニードルの安全性の検証2018

    • Author(s)
      菅原正秋、高山美歩、矢嶌裕義、高倉伸有
    • Organizer
      第67回全日本鍼灸学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 鍼感覚質問紙(日本語版MASS)を用いた鍼感覚の検討(第1報)-刺入深度による鍼感覚の違い-2017

    • Author(s)
      西脇政子、矢嶌裕義、高山美歩、奈須守洋、大渕修哉、高倉伸有
    • Organizer
      第66回全日本鍼灸学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Double-blind acupuncture needles: A multi-needle, multi-session feasibility study.2017

    • Author(s)
      Schlaeger JM, Takakura N, Yajima H, Takayama M, Steffen AD, Gabzdyl EM, Nisi RA, McGowan Gruber KM, Bussell JM, Wilkie DJ.
    • Organizer
      University of Illinois at Chicago Center for Research on Women and Gender, Women's Health Research Day.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] No Penetrating Sensations with Japanese Acupuncture?2016

    • Author(s)
      Hiroyoshi Yajima, Miho Takayama, Akiko Kawase, Chikako Hirakawa, Nobuari Takakura
    • Organizer
      WFAS Tokyo/Tsukuba 2016 (世界鍼灸学会連合会学術大会)
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2016-11-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Japanese Version of the Massachusetts General Hospital Acupuncture Sensation Scale: Validation2016

    • Author(s)
      Masako Nishiwaki, Miho Takayama, Hiroyoshi Yajima, Morihiro Nasu, Syuya Ohbuchi, Junko Hirota, Nobuari Takakura
    • Organizer
      WFAS Tokyo/Tsukuba 2016 (世界鍼灸学会連合会学術大会)
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2016-11-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Double-blind Acupuncture Needles: A Multineedle, Multisession Feasibility Study2016

    • Author(s)
      Judith M. Schlaeger, Nobuari Takakura, Hiroyoshi Yajima, Miho Takayama, Alana D. Steffen, Elizabeth M. Gabzdyl, Diana J. Wilkie
    • Organizer
      International Association for the Study of Pain (IASP)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 皮膚に接触する鍼による鎮痛効果 -ダブルブラインド法を用いて-2016

    • Author(s)
      高山美歩, 矢嶌裕義, 川瀬明子, 高倉伸有
    • Organizer
      第65回全日本鍼灸学会学術大会
    • Place of Presentation
      北海道 札幌コンベンションセンター
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
  • [Presentation] ダブルブラインド用非刺入鍼による皮膚感覚と患者ブラインド効果2016

    • Author(s)
      奈須守洋, 高山美歩, 矢嶌裕義, 広田順子, 西脇政子, 平川稚佳子, 高倉伸有
    • Organizer
      第65回全日本鍼灸学会学術大会
    • Place of Presentation
      北海道 札幌コンベンションセンター
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
  • [Presentation] 鍼感覚質問紙「日本語版MASS(案)」の信頼性と妥当性の検討 -合谷穴への鍼刺激によるパイロット試験-2016

    • Author(s)
      西脇政子, 高山美歩, 矢嶌裕義, 奈須守洋, 広田順子, 高倉伸有
    • Organizer
      第65回全日本鍼灸学会学術大会
    • Place of Presentation
      北海道 札幌コンベンションセンター
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
  • [Presentation] ダブルブラインド用の鍼のマスキング効果 -委中穴への鍼刺激-2015

    • Author(s)
      脇本美優、大渕修哉、平松燿、矢嶌裕義、高山美歩、高倉伸有
    • Organizer
      第63回全日本鍼灸学会学術大会
    • Place of Presentation
      ビッグパレットふくしま(福島)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Double-blind (practitioner-patient masking) placebo needle 7 -鍼体の太さが術者の鍼判別に及ぼす影響-2015

    • Author(s)
      矢嶌裕義、高山美歩、柳沢ゆかり、平川稚佳子、川瀬明子、高倉伸有
    • Organizer
      第63回全日本鍼灸学会学術大会
    • Place of Presentation
      ビッグパレットふくしま(福島)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2022-02-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi