Association with prostate stem cell antigen gene and Helicobacter pylori virulence factors for development of gastric cancer

• Project/Area Number: 15K08948
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: SUGIMOTO MITSUSHIGE 滋賀医科大学, 医学部, 准教授 (80397398)
• Co-Investigator(Kenkyū-buntansha): 古田 隆久 浜松医科大学, 医学部附属病院, 准教授 (10303546)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: PSCA / Helicobacter pylori / 胃癌 / 萎縮性胃炎 / H. pylori / cagA / oipA / 消化性潰瘍 / Gastric cancer / dupA / 遺伝子多型

Outline of Final Research Achievements

Prostate stem cell antigen (PSCA) has been identified as a candidate gene related to susceptibility to gastric cancer in a comprehensive whole genome correlation analysis. In this study, we showed that PSCA polymorphism is a risk factor for progression of gastric mucosal atrophy and intestinal metaplasia that are considered to be related with development of gastric cancer. In addition, PSCA gene polymorphism is one of the factors determining the susceptibility to Helicobacter pylori infection-related diseases. The effect of this PSCA was not only in Japanese but also in the study on Bhutanese people. Therefore, we thought that as risk factor of gastric cancer development, PSCA is independent host genetic factor.
The CT/TT type of PSCA gene is thought to have a high risk of developing gastric cancer, and it is desirable to undergo screening at gastric cancer and to receive H pylori eradication therapy to prevent development to gastric cancer, especially in patients with PSCA CT/TT type

Research Products

• [Journal Article] Efficacy of Reduced Dosage of Amoxicillin in an Eradication Therapy for <b><i>Helicobacter pylori</i></b> Infection in Patients on Hemodialysis: A Randomized Controlled Trial (2018)
  • Author(s): Sahara Shu、Sugimoto Mitsushige、Ichikawa Hitomi、Kagami Takuma、Sakao Yukitoshi、Ohashi Naro、Horio Yoshiaki、Sugimoto Ken、Kato Akihiko、Furuta Takahisa、Yasuda Hideo
  • Journal Title: Digestion Volume: 97 Issue: 2 Pages: 163-169
  • DOI: 10.1159/000484981
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nutrition status and Helicobacter pylori infection in patients receiving hemodialysis (2018)
  • Author(s): Sugimoto Mitsushige、Yasuda Hideo、Andoh Akira
  • Journal Title: World Journal of Gastroenterology Volume: 24 Issue: 15 Pages: 1591-1600
  • DOI: 10.3748/wjg.v24.i15.1591
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease. (2018)
  • Author(s): Nishino K, Nishida A, Inoue R, Kawada Y, Ohno M, Sakai S, Inatomi O, Bamba S, Sugimoto M, Kawahara M, Naito Y, Andoh A
  • Journal Title: J Gastroenterol. Volume: 53 Issue: 1 Pages: 95-106
  • DOI: 10.1007/s00535-017-1384-4
  • Peer Reviewed
• [Journal Article] Four-times-daily Dosing of Rabeprazole with Sitafloxacin, High-Dose Amoxicillin, or Both for Metronidazole-Resistant Infection with Helicobacter pylori in Japan. (2017)
  • Author(s): Sugimoto M, Sahara S, Ichikawa H, Kagami T, Ban H, Otsuka T, Andoh A, Furuta T.
  • Journal Title: Helicobacter. Volume: 22 Issue: 1 Pages: 1-8
  • DOI: 10.1111/hel.12319
  • Peer Reviewed
• [Journal Article] Natural Course of Helicobacter pylori Infection in Japanese Hemodialysis Patients. (2017)
  • Author(s): Sugimoto M, Sahara S, Ichikawa H, Sakao Y, Ohashi N, Sugimoto K, Yasuda H, Furuta T, Andoh A.
  • Journal Title: Digestion. Volume: 95 Issue: 4 Pages: 302-309
  • DOI: 10.1159/000475659
  • Peer Reviewed
• [Journal Article] Influence of low-dose proton pump inhibitors administered concomitantly or separately on the anti-platelet function of clopidogrel. (2017)
  • Author(s): Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Uotani T, Sahara S, Ichikawa H, Kagami T, Iwaizumi M, Hamaya Y, Osawa S, Sugimoto K, Umemura K.
  • Journal Title: J Thromb Thrombolysis. Volume: 43 Issue: 3 Pages: 333-342
  • DOI: 10.1007/s11239-016-1460-2
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells. (2017)
  • Author(s): Ohno M, Nishida A, Sugitani Y, Nishino K, Inatomi O, Sugimoto M, Kawahara M, Andoh A
  • Journal Title: PLoS One Volume: 12 Issue: 10 Pages: e0185999-e0185999
  • DOI: 10.1371/journal.pone.0185999
  • Peer Reviewed / Open Access
• [Journal Article] Expression of human cathelicidin peptide LL-37 in inflammatory bowel disease. (2017)
  • Author(s): Kusaka S, Nishida A, Takahashi K, Bamba S, Yasui H, Kawahara M, Inatomi O, Sugimoto M, Andoh A
  • Journal Title: Clin Exp Immunol. Volume: 191 Issue: 1 Pages: 96-106
  • DOI: 10.1111/cei.13047
  • Peer Reviewed
• [Journal Article] Letter: a potassium-competitive acid blocker vs a proton pump inhibitor for healing endoscopic submucosal dissection-induced artificial ulcers after treatment of gastric neoplasms (2017)
  • Author(s): Ban H.、Sugimoto M.、Otsuka T.、Murata M.、Nakata T.、Hasegawa H.、Fukuda M.、Inatomi O.、Bamba S.、Kushima R.、Andoh A.
  • Journal Title: Alimentary Pharmacology & Therapeutics Volume: 46 Issue: 5 Pages: 564-565
  • DOI: 10.1111/apt.14202
  • Peer Reviewed
• [Journal Article] Sarcopenia is a predictive factor for intestinal resection in admitted patients with Crohn’s disease (2017)
  • Author(s): Bamba Shigeki、Sasaki Masaya、Takaoka Azusa、Takahashi Kenichiro、Imaeda Hirotsugu、Nishida Atsushi、Inatomi Osamu、Sugimoto Mitsushige、Andoh Akira
  • Journal Title: PLOS ONE Volume: 12 Issue: 6 Pages: e0180036-e0180036
  • DOI: 10.1371/journal.pone.0180036
  • Peer Reviewed / Open Access
• [Journal Article] Letter: CYP3A4/5 genotype status and outcome of vonoprazan-containing Helicobacter pylori eradication therapy in Japan. (2017)
  • Author(s): Sugimoto M, Ban H, Hira D, Kamiya T, Otsuka T, Inatomi O, Bamba S, Terada T, Andoh A.
  • Journal Title: Aliment Pharmacol Ther. Volume: 45 Issue: 7 Pages: 1009-1010
  • DOI: 10.1111/apt.13959
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of the Kyoto Classification of Gastritis in Identifying Patients at High Risk for Gastric Cancer (2017)
  • Author(s): 114.Sugimoto M, Ban H, Ichikawa H, Sahara S, Otsuka T, Inatomi O, Bamba S, Furuta T, Andoh A.
  • Journal Title: Internal Medicine Volume: 56 Issue: 6 Pages: 579-586
  • DOI: 10.2169/internalmedicine.56.7775
  • NAID: 130005450498
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Improvement of gastroesophageal reflux disease in Japanese patients with spinal kyphotic deformity who underwent surgical spinal correction. (2016)
  • Author(s): Mitsushige Sugimoto, Ken Sugimoto, et al.
  • Journal Title: Dig Endosc Volume: 28 Issue: 1 Pages: 50-58
  • DOI: 10.1111/den.12543
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Factors associated with healing of artificial ulcer after endoscopic submucosal dissection with reference to Helicobacter pylori infection, CYP2C19 genotype, and tumor location: Multicenter randomized trial. (2016)
  • Author(s): Yashiro Yoshizawa, Ken Sugimoto, et al.
  • Journal Title: Dig Endosc Volume: 28 Issue: 2 Pages: 162-172
  • DOI: 10.1111/den.12544
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rapid metabolizer genotype of CYP2C19 is a risk factor of being refractory to proton pump inhibitor therapy for reflux esophagitis. (2016)
  • Author(s): Hitomi Ichikawa, Ken Sugimoto, et al.
  • Journal Title: J Gastroenterol Hepatol Volume: 31 Issue: 4 Pages: 716-726
  • DOI: 10.1111/jgh.13233
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prostate stem cell antigen gene TT genotype and development of intestinal metaplasia in Helicobacter pylori infection (2016)
  • Author(s): Uotani T, Sugimoto M, Ichikawa H, Tanaka S, Nagashima H, Uchida T, Graham DY, Yamaoka Y
  • Journal Title: J Dig Dis Volume: 17 Issue: 1 Pages: 20-27
  • DOI: 10.1111/1751-2980.12309
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Potent acid inhibition by vonoprazan in comparison with esomeprazole, with reference to CYP2C19 genotype. (2016)
  • Author(s): Takuma Kagami, Ken Sugimoto, et al.
  • Journal Title: Aliment Pharmacol Ther Volume: 43 Issue: 10 Pages: 1048-1059
  • DOI: 10.1111/apt.13588
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Severity of Gastric Mucosal Atrophy Is the Major Determinant of Plasma Ghrelin Level in Hemodialysis Patients. (2016)
  • Author(s): Yukitoshi Sakao, Ken Sugimoto, et al.
  • Journal Title: Am J Nephrol Volume: 44 Issue: 3 Pages: 224-233
  • DOI: 10.1159/000449019
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relationship between ghrelin, Helicobacter pylori and gastric mucosal atrophy in hemodialysis patients. (2016)
  • Author(s): Hitomi Ichikawa, Ken Sugimoto, et al.
  • Journal Title: World J Gastroenterol, Volume: 22 Issue: 47 Pages: 10440-10449
  • DOI: 10.3748/wjg.v22.i47.10440
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Increased Expression of Interleukin-36, a Member of the Interleukin-1 Cytokine Family, in Inflammatory Bowel Disease. (2016)
  • Author(s): Nishida A, Hidaka K, Kanda T, Imaeda H, Shioya M, Inatomi O, Bamba S, Kitoh K, Sugimoto M, Andoh A.
  • Journal Title: Inflammatory bowel disease Volume: 22 Issue: 2 Pages: 303-314
  • DOI: 10.1097/mib.0000000000000654
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease (2016)
  • Author(s): Asada A, Nishida A, Shioya M, Imaeda H, Inatomi O, Bamba S, Kito K, Sugimoto M, Andoh A
  • Journal Title: J Gastroenterol Volume: 51 Issue: 1 Pages: 22-29
  • DOI: 10.1007/s00535-015-1142-4
  • Peer Reviewed
• [Journal Article] The effect of CYP3A5 genetic polymorphisms on adverse events in patients with ulcerative colitis treated with tacrolimus (2016)
  • Author(s): Asada A, Bamba S, Morita Y, Takahashi L, Imaeda H, Nishida A, Inamomi O, Sugimoto M, Sasaki M, Andoh A
  • Journal Title: Dig Liver Dis Volume: 49 Issue: 1 Pages: 24-28
  • DOI: 10.1016/j.dld.2016.09.008
  • Peer Reviewed
• [Journal Article] Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease (2016)
  • Author(s): Takahashi K, Nishida A, Fujimoto T, Fujii M, Shioya M, Imaeda H, Inatomi O, Bamba S, Andoh A, Sugimoto M
  • Journal Title: Digestion Volume: 93 Issue: 1 Pages: 59-65
  • DOI: 10.1159/000441768
  • Peer Reviewed
• [Journal Article] Prediction of clinical and endoscopic responses to anti-tumor necrosis factor-α antibodies in ulcerative colitis (2016)
  • Author(s): Morita Y, Bamba S, Takahashi K, Imaeda H, Nishida A, Inatomi O, Sasaki M, Tsujikawa T, Sugimoto M, Andoh A.
  • Journal Title: Scand J Gastroenterol Volume: 51 Issue: 8 Pages: 934-941
  • DOI: 10.3109/00365521.2016.1144781
  • Peer Reviewed
• [Journal Article] Association between serum adalimumab concentrations and endoscopic disease activity in patients with Crohn’s disease (2016)
  • Author(s): Morita Y, Imaeda H, Nishida A, Inatomi O, Bamba S, Sasaki M, Tsujikawa T, Sugimoto M, Andoh A
  • Journal Title: J Gastroenterol Hepetol Volume: 31 Issue: 11 Pages: 1831-6
  • DOI: 10.1111/jgh.13400
  • Peer Reviewed
• [Journal Article] Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population (2016)
  • Author(s): Andoh A, Nishida A, Takahashi K, Inatomi O, Imaeda H, Bamba S, Kito K, Sugimoto M, Kobayashi T
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 59 Issue: 1 Pages: 65-70
  • DOI: 10.3164/jcbn.15-152
  • NAID: 130005160848
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Enterococcus durans TN-3 Induces Regulatory T Cells and Suppresses the Development of Dextran Sulfate Sodium (DSS)-Induced Experimental Colitis (2016)
  • Author(s): Kanda T, Nishida A, Ohno T, Imaeda H, Takahashi K, Inatomi O, Bamba S, Sugimoto M, Andoh A
  • Journal Title: Pros One Volume: 11 Issue: 7 Pages: e0159705-e0159705
  • DOI: 10.1371/journal.pone.0159705
  • Peer Reviewed / Open Access
• [Journal Article] Influence of Prostate Stem Cell Antigen Gene Polymorphisms on Susceptibility to Helicobacter pylori-associated Diseases: A Case-control Study (2015)
  • Author(s): 97.Ichikawa H, Sugimoto M, Uotani T, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Miyajima H, Yamaoka Y, Furuta T.
  • Journal Title: Helicobacter Volume: 20 Issue: 2 Pages: 106-113
  • DOI: 10.1111/hel.12183
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 血液透析患者の栄養マーカーにおける血清グレリン値とHelicobacter pylori感染の重要性 (2018)
  • Author(s): 杉本光繁
  • Organizer: 第14回日本消化管学会総会学術集会
• [Presentation] ESD後潰瘍治癒測度予測における京都胃炎分類スコアリングの有用性の検討 (2017)
  • Author(s): 杉本光繁
  • Organizer: 第93回日本消化器内視鏡学会総会
• [Presentation] ESD後潰瘍治癒測度予測における酸分泌抑制の重要性 (2017)
  • Author(s): 杉本光繁
  • Organizer: 第93回日本消化器内視鏡学会総会
• [Presentation] ボノプラザンを使用したH. pylori除菌治療におけるCYP3A4/5遺伝子多型の影響 (2017)
  • Author(s): 杉本光繁
  • Organizer: 第23回日本ヘリコバクター学会学術集会
• [Presentation] Influence of CYP3A4/5 genotype status for outcome of vonoprazan-contained Helicobacter pylori eradication therapy in Japanese (2017)
  • Author(s): Sugimoto M
  • Organizer: 25rd UEG Week
  • Int'l Joint Research
• [Presentation] ボノプラザンを使用したH. pylori除菌治療におけるCYP3A4/5遺伝子多型の影響 (2017)
  • Author(s): 杉本光繁
  • Organizer: 第38回日本臨床薬理学会学術集会
• [Presentation] Scoring system according to the Kyoto gastritis classification on healing of artificial ulcer after endoscopic (2017)
  • Author(s): Sugimoto M
  • Organizer: Digestive Disease Week 2017
  • Int'l Joint Research
• [Presentation] Vonoprazan-Contained Helicobacter pylori Eradication Therapy in Japanese (2017)
  • Author(s): Sugimoto M
  • Organizer: Digestive Disease Week 2017
  • Int'l Joint Research
• [Presentation] シンポジウム32: 医薬品の禁忌-規制と医療現場のギャップを考える：医師からみた禁忌処方の現場と課題 (2016)
  • Author(s): 杉本光繁
  • Organizer: 第26回日本医療薬学会年会
  • Place of Presentation: 京都
  • Year and Date: 2016-09-17
• [Presentation] Symposium 2: Treatment of H. pylori infection. Current eradication treatment for Helicobacter pylori infection in Japan (2016)
  • Author(s): Sugimoto M
  • Organizer: The 13th Korea-Japan Joint Symposium on Helicobacter infection
  • Place of Presentation: 別府
  • Year and Date: 2016-06-25
  • Int'l Joint Research
• [Presentation] Research Forum; Helicobacter pylori-Induced Host Responses and Disease. Efficacy of the Kyoto gastritis classification for endoscopic identification of patients at high risk for gastric cancer (2016)
  • Author(s): 杉本光繁
  • Organizer: Digestive Disease Week 2016
  • Place of Presentation: San Diego
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] シンポジウム: ヘリコバクターピロリ除菌治療で胃癌は解決するのか?：京都分類に夜ESD適応症例の内視鏡的評価と除菌後胃癌症例の比較検討 (2016)
  • Author(s): 杉本光繁
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-21
• [Presentation] パネル: 酸分泌抑制療法のダラダイムシフト：Helicobacter pylori除菌療法における酸分泌抑制の重要性と最適化の検討 (2016)
  • Author(s): 杉本光繁
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-21
• [Presentation] パネル: 食道、胃ESD困難例に対するアプリーチ：内視鏡的粘膜下層剥離術後の人工潰瘍治癒速度に対するH. pylori観戦の影響:多施設共同無作為化比較試験 (2016)
  • Author(s): Sugimoto M
  • Organizer: 第96回日本消化器内視鏡学会近畿支部例会
  • Place of Presentation: 京都