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Functional analysis of small RNAs involved in tumorigenesis of a new molecular subtype of colorectal cancer, and investigation of their new molecular targets

Research Project

Project/Area Number 15K08962
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

TAKAHASHI MASANOBU  東北大学, 加齢医学研究所, 准教授 (00447161)

Research Collaborator TAKAHASHI Hidekazu  石巻赤十字病院, 腫瘍内科, 医師
KOBAYASHI Akihiro  東北大学, 加齢医学研究所, 大学院生
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsmiRNA / BRAF / 抗EGFR抗体 / 大腸がん / BRAF変異 / 大腸癌
Outline of Final Research Achievements

This study was aimed to identify specific miRNAs, a class of small RNAs, that could be involved in oncogenesis of a molecular subgroup, BRAF-mutated colorectal cancer, and clarify biological functions of the miRNAs. A genome-wide miRNA expression analysis and functional analysis using colorectal cancer cell lines revealed that a miRNA, significantly down-regulated in BRAF-mutated colorectal cancer, acts as a tumor suppressor and affects sensitivity to anti-EGFR therapy in colorectal cancer. We are now investigating the mechanism underlying the dysregulation of this miRNA and analyzing the miRNA-involving signaling pathways that may relate to the carcinogenesis and/or chemosensitivity. The results could lead to further developing novel targeted therapies of colorectal cancer.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Funded Workshop (1 results)

  • [Journal Article] microRNA-193a-3p is specifically down-regulated and acts as a tumor suppressor in BRAF-mutated colorectal cancer.2017

    • Author(s)
      Takahashi, H.,Takahashi, M.,Ohnuma, S.,Unno, M.,Yoshino, Y.,Ouchi, K.,Takahashi, S.,Yamada, Y.,Shimodaira, H.,Ishioka, C.:
    • Journal Title

      BMC Cancer

      Volume: 17 Issue: 1 Pages: 723-727

    • DOI

      10.1186/s12885-017-3739-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The G8 screening tool enhances prognostic value to ECOG performance status in elderly cancer patients: A retrospective, single institutional study.2017

    • Author(s)
      Takahashi M, Takahashi M, Komine K, Yamada H, Kasahara Y, Chikamatsu S, Okita A, Ito S, Ouchi K, Okada Y, Imai H, Saijo K, Shirota H, Takahashi S, Mori T, Shimodaira H, Ishioka C.
    • Journal Title

      PLoS One.

      Volume: 12(6) Issue: 6 Pages: e0179694-e0179694

    • DOI

      10.1371/journal.pone.0179694

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and safety of gemcitabine plus docetaxel in Japanese patients with unresectable or recurrent bone and soft tissue sarcoma: Results from a single-institutional analysis.2017

    • Author(s)
      Takahashi M, Komine K, Imai H, Okada Y, Saijo K, Takahashi M, Shirota H, Ohori H, Takahashi S, Chiba N, Mori T, Shimodaira H, Ishioka C.
    • Journal Title

      PLoS One.

      Volume: 12(5) Issue: 5 Pages: e0176972-e0176972

    • DOI

      10.1371/journal.pone.0176972

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and safety of denosumab versus zoledronic acid in delaying skeletal-related events in patients with gastrointestinal cancer, pancreas-biliary system cancer, and other rare cancers.2017

    • Author(s)
      Imai H, Saijo K, Yamada H, Ohuchi K, Okada Y, Komine K, Takahashi M, Takahashi S, Takahashi M, Shimodaira H, Ishioka C.
    • Journal Title

      J Bone Oncol

      Volume: 6 Pages: 37-40

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation status as a biomarker of anti-epidermal growth factor receptor treatment for metastatic colorectal cancer.2015

    • Author(s)
      Ouchi K, Takahashi S, Yamada Y, Tsuji S, Tatsuno K, Takahashi H, Takahashi N, Takahashi M, Shimodaira H, Aburatani H, Ishioka C.
    • Journal Title

      Cancer Science

      Volume: 106 Issue: 12 Pages: 1722-1729

    • DOI

      10.1111/cas.12827

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional Complementation Assay for 47 MUTYH Variants in a MutY-Disrupted Escherichia coli Strain.2015

    • Author(s)
      Komine K, Shimodaira H, Takao M, Soeda H, Zhang X, Takahashi M, Ishioka C.
    • Journal Title

      Human Mutation

      Volume: 36 Issue: 7 Pages: 704-711

    • DOI

      10.1002/humu.22794

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] microRNA-193a-3p acts as a tumor suppressor in BRAF-mutated colorectal cancer2016

    • Author(s)
      1.Takahashi H, Takahashi M, Takahashi S, Shimodaira H, Ishioka, C
    • Organizer
      AACR Annual Meeting 2016
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Funded Workshop] AACR Annual Meeting 20162016

    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-04-16
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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