Clincal validation and usefulness of diatolic myocardial fractional flow reserve in the assessment of myocardila ischemia
Project/Area Number |
15K09093
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Wakayama Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
猪野 靖 和歌山県立医科大学, 医学部, 講師 (00549793)
塩野 泰紹 和歌山県立医科大学, 医学部, 助教 (00584872)
久保 隆史 和歌山県立医科大学, 医学部, 准教授 (30316096)
西口 毅 和歌山県立医科大学, 医学部, 博士研究員 (40549771)
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Research Collaborator |
Ogasawara Yasuo 川崎医療福祉大学, 医療技術学部・臨床工学科, 特任教授
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 冠内圧 / 心筋血流予備量比 / 心筋虚血 / 心筋シンチグラフィー / 循環器・高血圧 / 生体機能利用 / 生理学 / 内科 |
Outline of Final Research Achievements |
Measurement system of diastolic myocardial fractional flow reserve (d-FFR), which was thought to be a new index of myocardial ischemia, has been developed using pressure recordings of FFR, and usefulness of it was assessed in clinical practice. Prospective registry named DIASTOLE study was performed in 450 cases, who were referred to coronary angiography due to angina pectoris, for estimating the diagnostic accuracy of d-FFR and FFR compared with the results of myocardial perfusion images as a gold standard. The registry was just completed, and the data were started to analyze in core laboratories. Final results would be presented in several scientific meetings and could be published in some journals in the near future.
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Academic Significance and Societal Importance of the Research Achievements |
心筋虚血指標として平均冠動脈内圧を用いた心筋血流予備量比(FFR)が用いられているが、冠動脈内圧-血流関係からは拡張期FFR (d-FFR)がより正確な心筋虚血の指標と考えられる。本研究ではd-FFRを計測するソフトウエアを開発し、d-FFRとFFRの診断精度を心筋シンチグラフィーをゴールドスタンダードとして比較する多施設共同研究を完了し、解析中である。d-FFRが心筋虚血評価に優れていることが証明されれば、d-FFRが新たな心筋虚血指標とされ、計測ソフトウエアの有用性が評価される可能性がある。
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Report
(5 results)
Research Products
(33 results)
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[Journal Article] Hyperaemic microvascular resistance predicts clinical outcome and microvascular injury after myocardial infarction.2018
Author(s)
de Waard GA, Fahrni G, de Wit D, Kitabata H, Williams R, Patel N, Teunissen PF, van de Ven PM, Umman S, Knaapen P, Perera D, Akasaka T, Sezer M, Kharbanda RK, van Royen N.
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Journal Title
Heart
Volume: 104
Issue: 2
Pages: 127-134
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Incidence and predictors of lesion-specific ischemia by FFRCT: Learnings from the international ADVANCE registry.2018
Author(s)
Kitabata H, Leipsic J, Patel MR, Nieman K, De Bruyne B, Rogers C, Pontone G, Nørgaard BL, Bax JJ, Raff G, Chinnaiyan KM, Rabbat M, Rønnow Sand NP, Blanke P, Fairbairn TA, Matsuo H, Amano T, Kawasaki T, Morino Y, Akasaka T.
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Journal Title
J Cardiovasc Comput Tomogr
Volume: 12
Issue: 2
Pages: 95-100
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Diagnostic Accuracy of Quantitative Flow Ratio for Assessing Myocardial Ischemia in Prior Myocardial Infarction2018
Author(s)
Emori H, Kubo T, Kameyama T, Ino Y, matsuo Y, Kitabata H, Terada K, Katayama Y, Aoki H, Taruya A, Shimamura K, Ota S, Tanaka A, Hozumi T, Akasaka T
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Journal Title
Circulation Journal
Volume: 82
Issue: 3
Pages: 807-814
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical imprications of three-vessel fractional flow reserve measurement in patients with coronary artery disease.2018
Author(s)
Lee JM, Koo BK, SHin ES, Nam CW, Doh JH, Hwang D, Park J, Kim KJ, Zhang J, Hu X, Wang J, Ahn C, Ye F, Chen S, Yang J, Chen J, Tanaka N, Yokoi H, Matsuo H, Takashima H, Shiono Y, Akasaka T
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Journal Title
Eur Heart J
Volume: 39
Issue: 11
Pages: 945-951
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical relevance of functionally insignificant moderate coronary artery stenosis assessed by 3-vessel fractional flow reserve measurement.2018
Author(s)
Park J, Lee JM, Koo BK, Shin ES, Nam CW, Doh JH, Hwang D, Zhang J, Hu X, Wang J, Ye F, Chen S, Yang J, Chen J, Tanaka N, Yokoi H, Matsuo H, Takashima H, Shiono Y, Akasaka T.
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Journal Title
J Am Heart Assoc
Volume: 7
Issue: 4
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Prognostic implication of functional incomplete revascularization and residual functional SYNTAX score in patients with coronary artery disease.2018
Author(s)
Choi KH, Lee JM, Koo BK, Nam CW, Shin ES, Doh JH, Rhee TM, Hwang D, Park J, Zhang J, Kim KJ, Hu X, Wang J, Ye F, Chen S, Yang J, Chen J, Tanaka N, Yokoi H, Matsuo H, Takashima H, Shiono Y, Akasaka T
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Journal Title
J Am Coll Cardiol Cardiovasc Interv
Volume: 11
Issue: 3
Pages: 237-245
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] One-Year Outcome of Fractional Flow Reserve-Based Coronary Intervention in Japanese Daily Practice ― CVIT-DEFER Registry ―2017
Author(s)
Tanaka N, Nakamura M, Akasaka T, Kadota K, Uemura S, Amano T, Shiode N, Morino Y, Fujii K, Hikichi Y; CVIT-DEFER Registry Investigators.
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Journal Title
Circulation Journal
Volume: 81
Issue: 9
Pages: 1301-1306
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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[Journal Article] Impact of functional focal versus diffuse coronary artery disease on bypass graft patency2016
Author(s)
15.Shiono Y, Kubo T, Honda K, Katayama Y, Aoki H, Satogami K, Kashiyama K, Taruya A, Nishiguchi T, Kuroi A, Orii M, Kameyama T, Yamano T, Yamaguchi T, Matsuo Y, Ino Y, Tanaka A, Hozumi T, Nishimura Y, Okamura Y, Akasaka T
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Journal Title
Int J Cardiol
Volume: 222
Pages: 16-21
Related Report
Peer Reviewed
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[Journal Article] Long-term outcome after deferral of revascularization in patients with intermediate coronary stenosis and gray-zone fractional flow reserve2015
Author(s)
Shiono Y, Kubo T, Tanaka A, Ino Y, Yamaguchi T, Tanimoto T, Yamano T, Matsuo Y, Nishiguchi T, Teraguchi I, Ota S, Ozaki Y, Orii M, Shimamura K, Kitabata H, Hirata K, Imanishi T, Akasaka T
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Journal Title
Circ J
Volume: 79
Pages: 91-95
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Usefulness of combined intravascular ultrasound parameters to predict functional significance of coronary artery stenosis and determinants of mismatch2015
Author(s)
Cho YK, Nam CW, Han JK, Koo BK, Doh JH, Ben-Dor I, Waksman R, Pichard A, Murata N, Tanaka N, Lee CH, Gonzalo N, Escaned J, Costa MA, Kubo T, Akasaka T, Hu X, Wang JA, Yang HM, Yoon MH, Tahk SJ, Yoon HJ, Chung IS, Hur SH, Kim KB
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Journal Title
Euro Intervention
Volume: 11
Pages: 163-170
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] The reproducibility of physiological mapping of coronary vessels by angio-coregistration with instantaneous wave-free ratio pullback.2018
Author(s)
Higashioka D, Shiono Y, Shimamura K, Kuroi A, Kameyama T, Matsuo Y, Kitabata H, Ino Y, Kubo T, Tanaka A, Hozumi T, Akasaka T.
Organizer
ESC 2018
Related Report
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[Presentation] FFR時代において冠動脈多肢病変患者に対して心筋シンチグラフィはどのように用いることが出来るか2015
Author(s)
青木 浩, 塩野泰紹, 折居 誠, 黒井彰央, 亀山剛義, 山野貴司, 山口智由, 松尾好記, 猪野 靖, 久保隆史, 田中 篤, 穂積健之, 赤阪隆史
Organizer
第119回日本循環器学会近畿地方会
Place of Presentation
大阪市
Year and Date
2015-06-20
Related Report
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[Presentation] Impact of the distribution of hemodynamically significant coronary stenosis assessed by fractional flow reserve on the patency of bypass graft2015
Author(s)
Shiono Y, Kubo T, Asae Y, Emori H, Higashioka D, Yamamoto Y, Taruya A, Nishio H, Nishiguchi T, Teraguchi I, Aoki M, Yamano t, Matsuo Y, Ino Y, Yamaguchi T, Hirata K, Tanaka A, Honda K, Okamura Y, Akasaka T
Organizer
The 79th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Osaka
Year and Date
2015-04-24
Related Report