| Project/Area Number |
15K09102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Research Collaborator |
KAWAI Makoto
MINAI Kosuke
NAGOSHI Tomohisa
OGAWA Kazuo
KIMURA Haruka
YOSHII Akira
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ナトリウム利尿ペプチド / 肥満 / インスリン抵抗性 / 心不全 / 虚血性心疾患 / 熱産生 / 臨床心臓学 / 狭心症 / 褐色脂肪細胞 / 糖尿病 |
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| Outline of Final Research Achievements |
We examined a relationship among natriuretic peptide (NP), obesity, insulin resistance (IR) and ischemic heart disease (IHD). We also examined a possible participation of NP in energy metabolism.
As a clinical study by using our clinical database, we found that 1) obesity strongly suppressed a rise in plasma BNP during acute heart failure, 2) obesity suppressed a rise of plasma BNP; and the inadequate plasma BNP potentially caused coronary atherosclerosis, and 3) IR was augmented during acute coronary syndrome. These results suggest that obesity, relatively-low plasma BNP, IR and IHD are strongly associated with each other. As a basic study, we investigated a possible thermogenic action of A-type NP (ANP) on rat brown adipocytes. The newly-formed experimental system clearly demonstrated the thermogenic action of ANP and an increase of uncoupling protein-1 (UCP1); and the increase in the intracellular temperature and the expression of UCP1 were cancelled by p38MAPK inhibition.
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