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A relationship among the low-reactivity of natriuretic peptide, insulin resistance and ischemic heart disease

Research Project

Project/Area Number 15K09102
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionJikei University School of Medicine

Principal Investigator

Yoshimura Michihiro  東京慈恵会医科大学, 医学部, 教授 (30264295)

Research Collaborator KAWAI Makoto  
MINAI Kosuke  
NAGOSHI Tomohisa  
OGAWA Kazuo  
KIMURA Haruka  
YOSHII Akira  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsナトリウム利尿ペプチド / 肥満 / インスリン抵抗性 / 心不全 / 虚血性心疾患 / 熱産生 / 臨床心臓学 / 狭心症 / 褐色脂肪細胞 / 糖尿病
Outline of Final Research Achievements

We examined a relationship among natriuretic peptide (NP), obesity, insulin resistance (IR) and ischemic heart disease (IHD). We also examined a possible participation of NP in energy metabolism.
As a clinical study by using our clinical database, we found that 1) obesity strongly suppressed a rise in plasma BNP during acute heart failure, 2) obesity suppressed a rise of plasma BNP; and the inadequate plasma BNP potentially caused coronary atherosclerosis, and 3) IR was augmented during acute coronary syndrome. These results suggest that obesity, relatively-low plasma BNP, IR and IHD are strongly associated with each other. As a basic study, we investigated a possible thermogenic action of A-type NP (ANP) on rat brown adipocytes. The newly-formed experimental system clearly demonstrated the thermogenic action of ANP and an increase of uncoupling protein-1 (UCP1); and the increase in the intracellular temperature and the expression of UCP1 were cancelled by p38MAPK inhibition.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (2 results)

  • [Journal Article] Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor2017

    • Author(s)
      Tsutsumi Joshi、Minai Kosuke、Kawai Makoto、Ogawa Kazuo、Inoue Yasunori、Morimoto Satoshi、Tanaka Toshikazu、Nagoshi Tomohisa、Ogawa Takayuki、Yoshimura Michihiro
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 5 Pages: e0177327-e0177327

    • DOI

      10.1371/journal.pone.0177327

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The thermogenic actions of natriuretic peptide in brown adipocytes: The direct measurement of the intracellular temperature using a fluorescent thermoprobe2017

    • Author(s)
      Kimura Haruka、Nagoshi Tomohisa、Yoshii Akira、Kashiwagi Yusuke、Tanaka Yoshiro、Ito Keiichi、Yoshino Takuya、Tanaka Toshikazu D.、Yoshimura Michihiro
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 12978-12978

    • DOI

      10.1038/s41598-017-13563-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possible increase in insulin resistance and concealed glucose-coupled potassium-lowering mechanisms during acute coronary syndrome documented by covariance structure analysis2017

    • Author(s)
      Ito Satoshi、Nagoshi Tomohisa、Minai Kosuke、Kashiwagi Yusuke、Sekiyama Hiroshi、Yoshii Akira、Kimura Haruka、Inoue Yasunori、Ogawa Kazuo、Tanaka Toshikazu D.、Ogawa Takayuki、Kawai Makoto、Yoshimura Michihiro
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 4 Pages: e0176435-e0176435

    • DOI

      10.1371/journal.pone.0176435

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potent influence of obesity on suppression of plasma B-type natriuretic peptide levels in patients with acute heart failure: An approach using covariance structure analysis.2016

    • Author(s)
      Kinoshita K, Kawai M, Minai K, Ogawa K, Inoue Y, Yoshimura M.
    • Journal Title

      Int J Cardiol.

      Volume: 215 Pages: 283-90

    • DOI

      10.1016/j.ijcard.2016.04.111

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] The impact of an inverse correlation between plasma B-type natriuretic peptide levels and insulin resistance on the diabetic condition in patients with heart failure.2016

    • Author(s)
      Inoue Y, Kawai M, Minai K, Ogawa K, Nagoshi T, Ogawa T, Yoshimura M.
    • Journal Title

      Metabolism.

      Volume: 65(3) Issue: 3 Pages: 38-47

    • DOI

      10.1016/j.metabol.2015.09.019

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Natriuretic Peptide Exerts Thermogenic Effects on Brown Adipocytes in a Low-Temperature-Sensitive Manner: Direct Measurement of Intracellular Temperature Using Fluorescent Thermoprobe2018

    • Author(s)
      木村 悠
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 心不全症例のインスリン抵抗性に対するナトリウム利尿ペプチドの潜在的作用.2015

    • Author(s)
      井上康憲.
    • Organizer
      第1回日本心筋症研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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