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Study of biomarkers in respiratory disease based on the expression analysis of miRNAs in blood and epithelial lining fluid.

Research Project

Project/Area Number 15K09179
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKagoshima University

Principal Investigator

SAMUKAWA Takuya  鹿児島大学, 医歯学域附属病院, 講師 (10363623)

Co-Investigator(Kenkyū-buntansha) 井上 博雅  鹿児島大学, 医歯学域医学系, 教授 (30264039)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords呼吸器疾患 / バイオマーカー / 気道上皮被覆液 / miRNA / napsin A / BAFF / miRNA発現解析 / 気管支鏡下マイクロサンプリング / 間質性肺炎 / 血液バイオマーカー
Outline of Final Research Achievements

1.Serum B cell-activating factor (BAFF) may be a useful marker for distinguish connective tissue disease associated interstitial lung disease from chronic fibrosing interstitial pneumonia. 2. miRNA-218 on lung squamous cell carcinoma directly regulates oncogenic TDP52 and appears to function as a tumor suppresser through targeting of TDP52. 3.Evaluation of napsin A levels in epithelial lining fluid may be useful for distinguishing primary lung adenocarcinoma.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Napsin A levels in epithelial lining fluid as a diagnostic biomarker of primary lung adenocarcinoma.2017

    • Author(s)
      Uchida T, Samukawa T, Kumamoto T, Ohshige M, Hatanaka K, Nakamura Y, Mizuno K, Higashimoto I, Sato M, Inoue H.
    • Journal Title

      BMC Pulm Med

      Volume: 17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of TPD52 by antitumor microRNA-218 suppresses cancer cell migration and invasion in lung squamous cell carcinoma2016

    • Author(s)
      Kumamoto T, Seki N, Mataki H, Mizuno K, Kamikawaji K, Samukawa T, Koshizuka K, Goto Y, Inoue H.
    • Journal Title

      Int J Oncol.

      Volume: 49 Issue: 5 Pages: 1870

    • DOI

      10.3892/ijo.2016.3690

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interstitial pneumonia induced by bleomycin treatment is exacerbated in Angptl2-deficient mice2016

    • Author(s)
      Motokawa I, Endo M, Terada K, Horiguchi H, Miyata K, Kadomatsu T, Morinaga J, Sugizaki T, Ito T, Araki K, Morioka MS, Manabe I, Samukawa T, Watanabe M, Inoue H, Oike Y.
    • Journal Title

      American Journal of Physiology. Lung Cellular and Molecular Physiology

      Volume: 311 Issue: 4 Pages: 704-713

    • DOI

      10.1152/ajplung.00005.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum B cell-activating factor (BAFF) level in connective tissue disease associated interstitial lung disease.2015

    • Author(s)
      Hamada T, Samukawa T, Kumamoto T, Hatanaka K, Tsukuya G, Yamamoto M, Machida K, Watanabe M, Mizuno K, Higashimoto I, Inoue Y, Inoue H.
    • Journal Title

      BMC Pulm Med

      Volume: 15 Issue: 1 Pages: 110-110

    • DOI

      10.1186/s12890-015-0105-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

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Published: 2015-04-16   Modified: 2019-03-29  

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