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Comparison of 3D constructed CT images and pathological findings of interstitial pneumonia

Research Project

Project/Area Number 15K09184
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNagoya City University

Principal Investigator

Ohkubo Hirotsugu  名古屋市立大学, 大学院医学研究科, 講師 (70408144)

Co-Investigator(Kenkyū-buntansha) 新實 彰男  名古屋市立大学, 大学院医学研究科, 教授 (30252513)
難波 大夫  名古屋市立大学, 大学院医学研究科, 講師 (40381793)
森山 悟  名古屋市立大学, 大学院医学研究科, 研究員 (50551264)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords間質性肺炎 / 3次元構築画像 / ボリュームレンダリング / 人工知能 / ディープラーニング / ボリュームレンダリング法 / 線維化性間質性肺炎 / CT / 画像解析 / 機械学習
Outline of Final Research Achievements

Our 3D constructed CT images using volume rendering method showed similar findings of the pathology (loupe findings) of interstitial lung disease. Heterogenicity was discovered in the 3D constructed CT images using volume rendering method, that was typical for usual interstitial pneumonia (UIP). Furthermore, honeycomb lung was found to be a funicular structure that was vertical from pleura. We found traction bronchiectasis surrounded by ground glass opacity was an important finding in UIP. In non-specific interstitial pneumonia, heterogeneity was not found in the 3D constructed CT images. We recruited larger cohort by multi-center study. The trial using deep learning method was ongoing for the diagnose of interstitial pneumonia.

Academic Significance and Societal Importance of the Research Achievements

本研究では、CT画像での判別が難解である間質性肺炎のCT画像から3次元画像を構築することで、将来の新しい間質性肺炎の診断方法に貢献したといえる。CTからの情報を病理所見と照らし合わせてその正確性を追求した。得られた結果は、予後不良である間質性肺炎のより優れた診断法につながり、治療選択においても意義のあるものへとつながっていくと考える。また、近年脚光を浴びている人工知能(AI)の研究へと発展させ、近未来の間質性肺炎診断にむけての研究を展開している。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (21 results)

All 2019 2018 2017 2016 2015

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 7 results) Presentation (11 results) (of which Int'l Joint Research: 2 results) Book (2 results)

  • [Journal Article] Remarkable Improvement in a Patient with Idiopathic Pulmonary Fibrosis after Treatment with Nintedanib2019

    • Author(s)
      Nakano A, Ohkubo H, Fukumitsu K, Fukuda S, Kanemitsu Y, Takemura M, Maeno K, Ito Y, Oguri T, Niimi A.
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 8 Pages: 1141-1144

    • DOI

      10.2169/internalmedicine.1890-18

    • NAID

      130007632765

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-04-15
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Volumetric Computed Tomography Analysis of the Normal Lung in Idiopathic Pulmonary Fibrosis: The Relationship with the Survival2018

    • Author(s)
      Ohkubo Hirotsugu、Taniguchi Hiroyuki、Kondoh Yasuhiro、Yagi Mitsuaki、Furukawa Taiki、Johkoh Takeshi、Arakawa Hiroaki、Fukuoka Junya、Niimi Akio
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 7 Pages: 929-937

    • DOI

      10.2169/internalmedicine.9508-17

    • NAID

      130006602648

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computer-based quantitative computed tomography image analysis in idiopathic pulmonary fibrosis: A mini review2018

    • Author(s)
      Ohkubo Hirotsugu、Nakagawa Hiroaki、Niimi Akio
    • Journal Title

      Respir Investig

      Volume: 56 Issue: 1 Pages: 5-13

    • DOI

      10.1016/j.resinv.2017.10.003

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Normal Lung Quantification in Usual Interstitial Pneumonia Pattern: The Impact of Threshold-based Volumetric CT Analysis for the Staging of Idiopathic Pulmonary Fibrosis.2016

    • Author(s)
      Ohkubo H, Kanemitsu Y, Uemura T, Takakuwa O, Takemura M, Maeno K, Ito Y, Oguri T, Kazawa N, Mikami R, Niimi A.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 3 Pages: e0152505-e0152505

    • DOI

      10.1371/journal.pone.0152505

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Summer-type hypersensitivity pneumonitis in a patient with rheumatoid arthritis on methotrexate and tacrolimus.2016

    • Author(s)
      Ohkubo H, Okayama M, Fukumitsu K, Niimi A.
    • Journal Title

      Respirol Case Rep

      Volume: 4 Issue: 6

    • DOI

      10.1002/rcr2.194

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Refractory Interstitial Lung Disease of Dermatomyositis: A Proposal for a Prospective Trial for Establishing Evidence2015

    • Author(s)
      Ohkubo H, Fukumitsu K, Niimi A.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 17 Pages: 2099-2100

    • DOI

      10.2169/internalmedicine.54.5035

    • NAID

      130005097138

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corticosteroid Treatment for Acute Respiratory Distress Syndrome2015

    • Author(s)
      Ohkubo H, Kawaguchi Y, Niimi A.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 12 Pages: 1463-1464

    • DOI

      10.2169/internalmedicine.54.4521

    • NAID

      130005075953

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A rare case of IgG4-related disease involving the uterus.2015

    • Author(s)
      Ohkubo H, Miyazaki M, Oguri T, Arakawa A, Kobashi Y, Niimi A.
    • Journal Title

      Rheumatology (Oxford)

      Volume: 54 Issue: 6 Pages: 1124-5

    • DOI

      10.1093/rheumatology/kev024

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Comparison of clinical characteristics and prognosis in patients with idiopathic pulmonary upper lobe predominant pulmonary fibrosis and idiopathic pulmonary fibrosis2018

    • Author(s)
      Hirotsugu Ohkubo, Kensuke Fukumitsu, Satoshi Fukuda, Yoshihiro Kanemitsu , Masaya Takemura, Ken Maeno, Yutaka Ito , Akio Niimi
    • Organizer
      European Respiratory Society internatinal congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 特発性肺線維症におけるCT画像から算出された正常肺体積%と予後との検討2017

    • Author(s)
      大久保仁嗣、谷口 博之、近藤 康博、上甲 剛、荒川 浩明、古川 大記、八木 光昭、福岡 順也、新実彰男
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム、東京都千代田区
    • Year and Date
      2017-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] 特発性肺線維症におけるCT画像から算出された正常肺体積%と予後との検討2017

    • Author(s)
      大久保仁嗣、谷口 博之、近藤 康博、上甲 剛、荒川 浩明、古川 大記、八木 光昭、福岡 順也、新実彰男
    • Organizer
      第9回呼吸機能イメージング研究会
    • Place of Presentation
      京都大学 百周年時計台記念館、京都府京都市
    • Year and Date
      2017-01-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 特発性肺線維症におけるCT画像から算出された正常肺体積%と予後との検討2017

    • Author(s)
      大久保仁嗣,谷口博之,近藤康博,上甲 剛,荒川浩明,古川大記,八木光昭,福岡
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] Quantitative assessment of erector spinae muscles by CT in patients with idiopathic pulmonary fibrosis.2017

    • Author(s)
      Hirotsugu Ohkubo, Yoshihiro Kanemitsu, Hiroyuki Taniguchi, Yasuhiro Kondoh, Taiki Furukawa, Akio Niimi.
    • Organizer
      Europian Respiratory Society International Congress 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Volumetric CT analysis of normal lung as a predictor of mortality in idiopathic pulmonary fibrosis2016

    • Author(s)
      Hirotsugu Ohkubo, Mitsuaki Yagi, Yasuhiro Kondoh, Takeshi Johkoh, Hiroaki Arakawa, Akio Niimi,and Hiroyuki Taniguchi
    • Organizer
      欧州呼吸器学会 2016
    • Place of Presentation
      エクセルロンドン会場、ロンドン、イギリス
    • Year and Date
      2016-09-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 関節リウマチ治療中に夏型過敏性肺炎を発症した1例2016

    • Author(s)
      岡山 未奈実、大久保 仁嗣、村瀬 博紀、金光 禎寛、上村 剛大、高桑 修、竹村 昌也、伊藤 穣、前野 健、小栗 鉄也、中村 敦、新実 彰男
    • Organizer
      第109回日本呼吸器学会東海地方学会
    • Place of Presentation
      名古屋市中小企業振興会館、愛知県名古屋市
    • Year and Date
      2016-05-21
    • Related Report
      2015 Research-status Report
  • [Presentation] IPFの予後予測因子(将来のステージ分類への展望)2016

    • Author(s)
      大久保仁嗣
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館、京都府、京都市
    • Year and Date
      2016-04-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Normal Lung Quantification in Usual Interstitial Pneumonia Pattern: The Impact of Threshold-based Volumetric CT Analysis for the Staging of Idiopathic Pulmonary Fibrosis2015

    • Author(s)
      Hirotsugu Ohkubo , Yoshihiro Kanemitsu, Takehiro Uemura, Eiji Kunii, Osamu Takakuwa, Masaya Takemura, Ken Maeno, Yutaka Ito, Tetsuya Oguri, and Akio Niimi.
    • Organizer
      7th International Workshop of Pulmonary Function Imaging
    • Place of Presentation
      英国、スコットランド、エディンバラ大学
    • Year and Date
      2015-09-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 特発性肺線維症の急性増悪に対するピルフェニドン併用ステロイド治療の有用性2015

    • Author(s)
      大久保仁嗣,福光研介,武田典久,福田悟史,浅野貴光,市川博也,國井英治,川口裕子,上村剛大,高桑 修,竹村昌也,前野 健,伊藤 穣,小栗鉄也,中村 敦,新実彰男
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム、東京都千代田区
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 特発性肺線維症におけるCT画像肺体積分析の臨床的有用性2015

    • Author(s)
      大久保仁嗣,福光研介,武田典久,福田悟史,浅野貴光,市川博也,國井英治,川口裕子,上村剛大,高桑 修,竹村昌也,前野 健,伊藤 穣,小栗鉄也,中村 敦,新実彰男
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム、東京都千代田区
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
  • [Book] 日本医事新報2016

    • Author(s)
      大久保 仁嗣、新実 彰男
    • Total Pages
      1
    • Publisher
      (株)日本医事新報社
    • Related Report
      2016 Research-status Report
  • [Book] 膠原病・リウマチ・アレルギー 研修ノート2016

    • Author(s)
      大久保仁嗣、新実彰男、他
    • Total Pages
      578
    • Publisher
      診断と治療社
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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