| Project/Area Number |
15K09194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
Hara Hiromichi 東京慈恵会医科大学, 医学部, 講師 (70398791)
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| Co-Investigator(Kenkyū-buntansha) |
荒屋 潤 東京慈恵会医科大学, 医学部, 講師 (90468679)
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| Co-Investigator(Renkei-kenkyūsha) |
KUWANO KAZUYOSHI 東京慈恵会医科大学, 医学部, 教授 (40205266)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 間質性肺炎 / PGE-MUM / 特発性肺線維症 |
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| Outline of Final Research Achievements |
We explored the clinical usefulness of measuring stable prostaglandin E- major urinary metabolite (PGE-MUM) with respect to pathogenesis and extent of chronic fibrosing IP (CFIP), including idiopathic pulmonary fibrosis (IPF). Compared to control, PGE-MUM levels were significantly elevated in CFIP. PGE-MUM levels were positively correlated with FS, and inversely correlated with %DLCO in IP. PGE-MUM can be a promising biomarker reflecting disease activity in CFIP. COX-2 was highly expressed in metaplastic epithelial cells in IPF, suggesting that these cells are major sources of elevated PGE-MUM in IPF.
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