Clinical evaluation of PGE-MUM as a biomarker in IPF
Project/Area Number |
15K09194
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Jikei University School of Medicine |
Principal Investigator |
Hara Hiromichi 東京慈恵会医科大学, 医学部, 講師 (70398791)
|
Co-Investigator(Kenkyū-buntansha) |
荒屋 潤 東京慈恵会医科大学, 医学部, 講師 (90468679)
|
Co-Investigator(Renkei-kenkyūsha) |
KUWANO KAZUYOSHI 東京慈恵会医科大学, 医学部, 教授 (40205266)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 間質性肺炎 / PGE-MUM / 特発性肺線維症 |
Outline of Final Research Achievements |
We explored the clinical usefulness of measuring stable prostaglandin E- major urinary metabolite (PGE-MUM) with respect to pathogenesis and extent of chronic fibrosing IP (CFIP), including idiopathic pulmonary fibrosis (IPF). Compared to control, PGE-MUM levels were significantly elevated in CFIP. PGE-MUM levels were positively correlated with FS, and inversely correlated with %DLCO in IP. PGE-MUM can be a promising biomarker reflecting disease activity in CFIP. COX-2 was highly expressed in metaplastic epithelial cells in IPF, suggesting that these cells are major sources of elevated PGE-MUM in IPF.
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Report
(4 results)
Research Products
(1 results)
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[Journal Article] 2. Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia.2017
Author(s)
Horikiri T, Hara H, Saito N, Araya J, Takasaka N, Utsumi H, Yanagisawa H, Hashimoto M, Yoshii Y, Wakui H, Minagawa S, Ishikawa T, Shimizu K, Numata T, Arihiro S, Kaneko Y, Nakayama K, Matsuura T, Matsuura M, Fujiwara M, Okayasu I, Ito S, Kuwano K.
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Journal Title
Respir Med.
Volume: 122
Pages: 43-50
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant