Leptin induces activation of human lung fibroblasts

Research Project

Project/Area Number	15K09202
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Respiratory organ internal medicine
Research Institution	Tokyo National Hospital (Clinical research)
Principal Investigator	Tashimo Hiroyuki 独立行政法人国立病院機構東京病院(臨床研究部), 臨床研究部, アレルギー科医長 (00407933)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	レプチン / 線維芽細胞 / アレルギー / 喘息 / 肥満 / アディポカイン / Ob-R
Outline of Final Research Achievements	One of the adipokines, leptin, is reported to activate inflammatory cell-types especially in Th2 type inflammation such as asthma. In severe asthma, fibroblasts play pivotal roles in formation of airway remodeling. Therefore, in the present study, we elucidated the effect of leptin on functions of human lung fibroblast. We found leptin dose-dependently upregulated inflammatory cytokine production by human lung fibroblasts. In addition, leptin promoted proliferation of human lung fibroblasts. We also found that human lung fibroblasts expressed leptin receptor on their surface. From the present study, activation of lung fibroblasts by leptin may be one of the mechanisms by which obesity aggravates asthma.