Basic research aiming at the application of SCGB3A2 for chronic obstructive pulmonary disease therapeutic drug.
| Project/Area Number |
15K09208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Yamagata University |
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Principal Investigator |
Kurotani Reiko 山形大学, 大学院理工学研究科, 准教授 (00453043)
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| Co-Investigator(Kenkyū-buntansha) |
阿部 宏之 山形大学, 大学院理工学研究科, 教授 (10375199)
今野 博行 山形大学, 大学院理工学研究科, 准教授 (50325247)
柴田 陽光 山形大学, 医学部, 講師 (60333978)
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| Co-Investigator(Renkei-kenkyūsha) |
KUMAKI Nobue 東海大学, 医学部, 講師 (90366021)
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| Research Collaborator |
ONO Sotaro
KINOSHITA Takamune
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | SCGB3A2 / COPD / 肺気腫 / STAT / A1AT / STAT1 / STAT3 |
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| Outline of Final Research Achievements |
In this study, we aimed at basic research aiming at application of secretoglobin (SCGB) 3A2 to chronic obstructive pulmonary disease (COPD) treatment. COPD is a lung disease considered to be one of lifestyle-related diseases caused by long-term smoking, and shows features such as thickening, stenosis of the peripheral airway wall and destruction of the alveolar wall. SCGB3A2 has an anti-inflammatory effect, an improvement effect of pulmonary fibrosis, and a growth promoting effect in lung development. Therefore, we expected that SCGB 3 A 2 will also have an effective effect on COPD. Mainly, the improvement effect of SCGB3A2 on COPD was examined using COPD mouse model prepared using Scgb3a2 gene modified mouse. In addition, we clarified the COPD improvement mechanism in the cell culture system. This study suggested that SCGB3A2 upregulates the expression of alpha 1 antitrypsin by phosphorylation of STAT3, and SCGB3A2 showed an effect of improving pulmonary emphysema, in particular.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway.2017
Author(s)
Huiling Jin, Takayuki Fujita, Meihua Jin, Reiko Kurotani, Iyuki Namekata, Shogo Hamaguchi, Yuko Hidaka, Wenqian Cai, Kenji Suita, Yoshiki Ohnuki, Yasumasa Mototani, Kouichi Shiozawa, Rajesh Prajapati, Chen Liang, Masanari Umemura, Utako Yokoyama, Motohiko Sato, Hikaru Tanaka, Satoshi Okumura, Yoshihiro Ishikawa.
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Journal Title
J Mol Cell Cardiol.
Volume: 108
Pages: 170-180
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Generation of camelid VHH bispecific constructs via in-cell intein-mediated protein trans-splicing2017
Author(s)
Yuki Shibuya, Natsuki Haga, Ryutaro Asano, Hikaru Nakazawa, Takamitsu Hattori, Daisuke Takeda Aruto Sugiyama, Reiko Kurotani, Izumi Kumagai, Mitsuo Umetsu, Koki Makabe
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Journal Title
Protein Engineering, Design & Selection
Volume: 30
Pages: 15-21
DOI
Related Report
Peer Reviewed
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[Presentation] Secretoglobin3A2 suppresses pulmonary emphysema2016
Author(s)
Reiko Kurotani, Sotaro Ono, Takamune Kinoshita, Yasuko Arai, Hiroyuki Abe
Organizer
the 22nd International Congress of Zoology and the87th meeting of Zoological Society of Japan
Place of Presentation
Okinawa Convention Center, Okinawa
Year and Date
2016-11-17
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