Evaluation of functions of ZC3H12A/MCPIP in airway inflammation
| Project/Area Number |
15K09211
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
城 大祐 東京大学, 大学院医学系研究科(医学部), 特任准教授 (30376470)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 慢性気道炎症性疾患 / 気道上皮細胞 / ZC3H12A/MCPIP / 細胞内シグナリング経路 / 免疫調整因子 / 慢性閉塞性肺疾患 / 気道炎症 / ZC3H12A / 炎症性サイトカイン / COPD |
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| Outline of Final Research Achievements |
The expression of ZC3H12A/MCPIP in airway epithelial cells was induced by stimulation with IL-17 and TNF-α. Co-stimulation with both IL-17 and TNF-α enhanced the expression of it, synergisticcaly. ZC3H12A/MCPIP may affect some of the intracellular signaling pathway associated with airway inflammation in airway epithelial cells.
The ZC3H12A/MCPIP may have important roles and function in the airway inflammatory disease.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性の気道炎症性疾患における炎症性病態の制御に向けて、吸入療法による治療targetとなり得る気道上皮細胞に着目し、細胞内でのZC3H12A/MCPIPの発現や機能について検討した。気道上皮細胞内のZC3H12A/MCPIPは、炎症性病態の条件で誘導され、また免疫調整因子として細胞内のsignaling pathwayに影響している可能性がある。
気道炎症性疾患の治療targetの候補として、今後、更なる検討が必要な状況であると考える。
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Report
(5 results)
Research Products
(5 results)
