Evaluation of functions of ZC3H12A/MCPIP in airway inflammation

• Project/Area Number: 15K09211
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: YAMAUCHI YASUHIRO 東京大学, 医学部附属病院, 講師 (00323585)
• Co-Investigator(Kenkyū-buntansha): 城 大祐 東京大学, 大学院医学系研究科(医学部), 特任准教授 (30376470)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 慢性気道炎症性疾患 / 気道上皮細胞 / ZC3H12A/MCPIP / 細胞内シグナリング経路 / 免疫調整因子 / 慢性閉塞性肺疾患 / 気道炎症 / ZC3H12A / 炎症性サイトカイン / COPD

Outline of Final Research Achievements

The expression of ZC3H12A/MCPIP in airway epithelial cells was induced by stimulation with IL-17 and TNF-α. Co-stimulation with both IL-17 and TNF-α enhanced the expression of it, synergisticcaly. ZC3H12A/MCPIP may affect some of the intracellular signaling pathway associated with airway inflammation in airway epithelial cells.
The ZC3H12A/MCPIP may have important roles and function in the airway inflammatory disease.

Academic Significance and Societal Importance of the Research Achievements

慢性の気道炎症性疾患における炎症性病態の制御に向けて、吸入療法による治療targetとなり得る気道上皮細胞に着目し、細胞内でのZC3H12A/MCPIPの発現や機能について検討した。気道上皮細胞内のZC3H12A/MCPIPは、炎症性病態の条件で誘導され、また免疫調整因子として細胞内のsignaling pathwayに影響している可能性がある。
気道炎症性疾患の治療targetの候補として、今後、更なる検討が必要な状況であると考える。

Research Products

• [Journal Article] Effect of outpatient therapy with inhaled corticosteroids on decreasing in-hospital mortality from pneumonia in patients with COPD. (2016)
  • Author(s): Yamauchi Y, Yasunaga H, Hasegawa W, Sakamoto Y, Takeshima H, Jo T, Matsui H, Fushimi K, Nagase T
  • Journal Title: Int J Chron Obstruct Pulmon Dis Volume: 11 Pages: 1403-1411
  • DOI: 10.2147/copd.s107985
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mortality associated with bone fractures in COPD patients (2016)
  • Author(s): Yamauchi Y, Yasunaga H, Sakamoto Y, Hasegawa W, Takeshima H, Urushiyama H, Jo T, Matsui H, Fushimi K, Nagase T.
  • Journal Title: Int J Chron Obstruct Pulmon Dis Volume: 11 Pages: 2335-2340
  • DOI: 10.2147/copd.s112142
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Interleukin-17A and Toll-Like Receptor 3 Ligand Poly(I:C) Synergistically Induced Neutrophil Chemoattractant Production by Bronchial Epithelial Cells. (2015)
  • Author(s): MatsuzakiH, Mikami Y, Yamauchi Y ,et al.
  • Journal Title: PLoS One Volume: 10 Issue: 10 Pages: 10-10
  • DOI: 10.1371/journal.pone.0141746
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of clinical characteristics and outcomes between aspiration pneumonia and community-acquired pneumonia in patients with chronic obstructive pulmonary disease. (2015)
  • Author(s): Yamauchi Y, Yasunaga H, Matsui H, et al.
  • Journal Title: BMC Pulm Med Volume: 15 Issue: 1 Pages: 69-69
  • DOI: 10.1186/s12890-015-0064-5
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of in-hospital mortality in patients with COPD, asthma and asthma-COPD overlap exacerbations. (2015)
  • Author(s): Yamauchi Y, Yasunaga H, Matsui H, et al.
  • Journal Title: Respirology Volume: 20 Issue: 6 Pages: 940-946
  • DOI: 10.1111/resp.12556
  • Peer Reviewed