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Monitoring of Emerging Resistance of Lung Cancer using Liquid Biopsy

Research Project

Project/Area Number 15K09239
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionAsahikawa Medical College

Principal Investigator

TANNO Sachie  旭川医科大学, 医学部, 客員助教 (80455724)

Co-Investigator(Kenkyū-buntansha) 水上 裕輔  旭川医科大学, 医学部, 准教授 (30400089)
小野 裕介  医療法人徳洲会札幌東徳洲会病院医学研究所, 臨床生体情報解析部, 部門長 (40742648)
佐々木 高明  旭川医科大学, 医学部, 助教 (70516997)
Research Collaborator YOSHIDA Ryouhei  旭川医科大学, 医学部, 助教 (40792883)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords液体生検 / デジタルPCR / 肺癌 / EGFR T790M / EGFR C797S / ALK G1202R / EGFR / ALK / KRAS / T790M
Outline of Final Research Achievements

Pre and Post surgical Lung adenocarcinoma samples were analyzed by ddPCR. 5 cases of EGFR or KRAS were analyzed. Because of the low amount of circulating tumor DNA, some of the samples were not detected any mutation.
We had collected 103 samples from 74 patients. T790M and C797S mutations were successfully analyzed.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] ALK阻害薬の耐性機序と次世代ALK阻害薬2017

    • Author(s)
      吉田遼平、 佐々木高明
    • Journal Title

      腫瘍内科

      Volume: 19/5 Pages: 526-531

    • Related Report
      2017 Annual Research Report
  • [Presentation] 血漿由来遊離核酸より微量変異を検出する感度の向上を目的としたデジタルPCR法の応用2017

    • Author(s)
      小野裕介
    • Organizer
      日本癌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ALK肺癌に対する耐性機序(未定)2016

    • Author(s)
      佐々木高明
    • Organizer
      日本肺癌学会
    • Place of Presentation
      福岡
    • Year and Date
      2016-12-21
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 非小細胞肺癌を対象としたデジタルPCRによるliquid biopsy2016

    • Author(s)
      小野 裕介, 佐々木 高明, 吉田 遼平, 安藤 清宏, 大崎 能伸, 水上 裕輔
    • Organizer
      日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 液体生検による肺がん診断の臨床応用2016

    • Author(s)
      佐々木高明、水上裕輔、小野祐介、丹野幸恵ら
    • Organizer
      日本臨床腫瘍学会
    • Place of Presentation
      神戸
    • Year and Date
      2016-07-30
    • Related Report
      2016 Research-status Report 2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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