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Novel therapeutic strategy with Vasohibin against acute kiney injury

Research Project

Project/Area Number 15K09263
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionOkayama University

Principal Investigator

Tanabe Katsuyuki  岡山大学, 大学病院, 助教 (40534805)

Co-Investigator(Renkei-kenkyūsha) SATO Yasufumi  東北大学, 加齢医学研究所, 教授 (50178779)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords急性腎障害 / 血管新生 / ミトコンドリア / 酸化ストレス / アポトーシス / Vasohibin
Outline of Final Research Achievements

In this study, antiangiogenic factor Vasohibin-1 (VASH1) heterozygous deficiency exacerbated cisplatin-induced acute kidney injury (AKI) with markedly decreased expression of mitochondrial antioxidative enzyme SOD2. Recombinant VASH1 increased SOD2 expression in cultured renal tubular cells. On the other hand, proangiogenic factor Vasohibin-2 (VASH2) homozygous deficiency again exacerbated ischemic-reperfusion AKI. Overexpression of VASH2 in cultured real tubular cells resulted in the inhibition of H2O2-induced apoptosis. Taken together, increased expression of VASH1 and VASH2 in renal tubular cells may be a novel therapeutic strategy against AKI.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016

All Presentation (11 results) (of which Int'l Joint Research: 3 results)

  • [Presentation] 腎疾患におけるVasohibin-2の役割に関する検討2018

    • Author(s)
      田邊克幸、益田加奈、谷村智史、三宅広将、津志田圭吾
    • Organizer
      第13回Vasohibin研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Deficiency of proangiogenic factor vasohibin-2 exacerbates acute kidney injury via impaired renal tubular cell survival2018

    • Author(s)
      Miyake H, Tanabe K, Masuda K, Tsushida K, Tanimura S, Sugiyama H, Sato Y, Wada J
    • Organizer
      International Society of Nephrology Frontier meeting 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 急性腎障害における血管新生促進因子Vasohibin-2の発現意義についての検討2017

    • Author(s)
      三宅広将、田邊克幸、津志田圭吾、益田加奈、杉山斉、佐藤靖史、和田淳
    • Organizer
      第60回日本腎臓学会学術総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2017-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 急性腎障害におけるVasohibin-1 及び-2 の発現意義についての検討2017

    • Author(s)
      田邊克幸、三宅広将、益田加奈、谷村智史、津志田圭吾
    • Organizer
      第12回Vasohibin研究会
    • Place of Presentation
      ラフォーレ蔵王(宮城県)
    • Year and Date
      2017-02-04
    • Related Report
      2016 Research-status Report
  • [Presentation] 急性腎障害における血管新生促進因子Vasohibin-2の発現意義についての検討2017

    • Author(s)
      三宅広将、田邊克幸、益田加奈、津志田圭吾、杉山斉、佐藤靖史、和田淳
    • Organizer
      第60回日本腎臓学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血管新生抑制因子Vasohibin-1の急性腎障害の発生への関与についての検討2017

    • Author(s)
      谷村智史、田邊克幸、益田加奈、三宅広将、津志田圭吾、杉山斉、佐藤靖史、和田淳
    • Organizer
      第60回日本腎臓学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Lack of vasohibin-1, a negative feedback regulator of angiogenesis, exacerbates renal injury in murine cisplatin nephropathy model2017

    • Author(s)
      Tanimura S, Tanabe K, Masuda K, Miyake H, Sugiyama H, Wada J
    • Organizer
      American Society of Nephrology Kidney Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic Deletion of Endogenous Proangiogenic Factor Vasohibin-2 Exacerbates Renal Ischemic Reperfusion Injury2016

    • Author(s)
      田邊克幸、益田加奈、荒田夕佳、杉山斉、和田淳
    • Organizer
      American Society of Nephrology Kidney Week 2016
    • Place of Presentation
      シカゴ(アメリカ合衆国)
    • Year and Date
      2016-11-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 急性腎障害における内因性血管新生促進因子Vasohibin-2の役割に関する検討2016

    • Author(s)
      田邊克幸、益田加奈、荒田夕佳、三宅広将、杉山斉、佐藤靖史、和田淳
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 急性腎障害における内因性血管新生促進因子Vasohibin-2の役割に関する検討2016

    • Author(s)
      田邊克幸
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 急性及び慢性の腎障害におけるVasohibin-2の発現意義についての検討2016

    • Author(s)
      田邊克幸
    • Organizer
      第11回Vasohibin研究会
    • Place of Presentation
      蔵王
    • Year and Date
      2016-01-23
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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