• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of MRP8 as a therapeutic target in chronic kidney disease

Research Project

Project/Area Number 15K09268
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKumamoto University

Principal Investigator

Kuwabara Takashige  熊本大学, 大学院生命科学研究部(医), 講師 (00393356)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords慢性炎症 / MRP8 / 半月体形成性腎炎 / マクロファージ / 糸球体内クロストーク / 糸球体腎炎 / 自然炎症 / 糸球体障害 / 細胞間クロストーク
Outline of Final Research Achievements

Chronic kidney disease (CKD) is one of the most prevalent diseases and leading to the necessity of renal replacement therapy, whose novel therapeutic stratedy is eagerly awaited. We have previously reported the role of chronic inflammation in CKD as well as diabetic nephropathy. In this study, we investigated the role of MRP8, one of the inflammatory endogenous ligands, in the crescentic glomerulonephritis. Our results suggested that ablation of MRP8 in myeloid cells ameliorated crescentic glomerulonephritis through affecting macrophage polarity.MRP8 could become as a theraputic target in glomerulonephritis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (29 results)

All 2018 2017 2016 2015 Other

All Journal Article (14 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 14 results,  Open Access: 11 results,  Acknowledgement Compliant: 10 results) Presentation (9 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response2018

    • Author(s)
      Miyasato Yoshikazu、Yoshizawa Tatsuya、Sato Yoshifumi、Nakagawa Terumasa、Miyasato Yuko、Kakizoe Yutaka、Kuwabara Takashige、Adachi Masataka、Ianni Alessandro、Braun Thomas、Komohara Yoshihiro、Mukoyama Masashi、Yamagata Kazuya
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 5927-5927

    • DOI

      10.1038/s41598-018-24257-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Obesity-promoting and anti-thermogenic effects of neutrophil gelatinase-associated lipocalin in mice2017

    • Author(s)
      Ishii Akira、Katsuura Goro、Imamaki Hirotaka、Kimura Hiroyuki、Mori Keita P.、Kuwabara Takashige、Kasahara Masato、Yokoi Hideki、Ohinata Kousaku、Kawanishi Tomoko、Tsuchida Junichi、Nakamoto Yuji、Nakao Kazuwa、Yanagita Motoko、Mukoyama Masashi、Mori Kiyoshi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 15501-15501

    • DOI

      10.1038/s41598-017-15825-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy2017

    • Author(s)
      Guan Yu、Nakano Daisuke、Zhang Yifan、Li Lei、Liu Wenhua、Nishida Motohiro、Kuwabara Takashige、Morishita Asahiro、Hitomi Hirofumi、Mori Kiyoshi、Mukoyama Masashi、Masaki Tsutomu、Hirano Katsuya、Nishiyama Akira
    • Journal Title

      J Pharmacol Sci

      Volume: 135 Issue: 2 Pages: 81-88

    • DOI

      10.1016/j.jphs.2017.09.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TSS-Seq analysis of low pH-induced gene expression in intercalated cells of the renal collecting duct2017

    • Author(s)
      Izumi Y
    • Journal Title

      PLos One

      Volume: 12 Issue: 8 Pages: e0184185-e0184185

    • DOI

      10.1371/journal.pone.0184185

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition.2017

    • Author(s)
      Y. Kato, K. Mori, M. Kasahara, K. Osaki, A. Ishii, K.P. Mori, N. Toda, S. Ohno, T. Kuwabara, T. Tokudome, I. Kishimoto, M.A. Saleem, T. Matsusaka, K. Nakao, M. Mukoyama, M. Yanagita, H. Yokoi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 46624-46624

    • DOI

      10.1038/srep46624

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Crucial role of mesangial cell-derived connective tissue growth factor in a mouse model of anti-glomerular basement membrane glomerulonephritis.2017

    • Author(s)
      Toda N, Mori K, Kasahara M, Ishii A, Koga K, Ohno S, Mori KP. Kato Y, Osaki K, Kuwabara T, Kojima K, Taura D, Sone M, Matsusaka T, Nakao K, Mukoyama M, Yanagita M, Yokoi H.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 42114-42114

    • DOI

      10.1038/srep42114

    • NAID

      120005997757

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.2017

    • Author(s)
      Mori KP, Yokoi H, Kasahara M, Imamaki H, Ishii A, Kuwabara T, Koga K, Kato Y, Toda N, Ohno S, Kuwahara K, Endo T, Nakao K, Yanagita M, Mukoyama M, Mori K.
    • Journal Title

      J Am Soc Nephrol.

      Volume: 28 Issue: 1 Pages: 278-289

    • DOI

      10.1681/asn.2015101168

    • NAID

      120005820888

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure.2016

    • Author(s)
      Ohno S, Yokoi H, Mori K, Kasahara M, Kuwahara K, Fujikura J, Naito M, Kuwabara T, Imamaki H, Ishii A, Saleem MA, Numata T, Mori Y, Nakao K, Yanagita M, Mukoyama M
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 27192-27192

    • DOI

      10.1038/srep27192

    • NAID

      120007100128

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mild systemic thermal therapy ameliorates renal dysfunction in a rodent model of chronic kidney disease.2016

    • Author(s)
      Iwashita Y, Kuwabara T, Hayata M, Kakizoe Y, Izumi Y, Iiyama J, Kitamura K, Mukoyama M.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: in press Issue: 11 Pages: 1-1

    • DOI

      10.1152/ajprenal.00519.2015

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Transthyretin-related familial amyloidotic polyneuropathy found with abnormal urinalysis at a general health checkup.2016

    • Author(s)
      Yoshimura Y, Kuwabara T, Shiraishi N, Kakizoe Y, Tasaki M, Obayashi K, Ando Y, Mukoyama M.
    • Journal Title

      Nephrology

      Volume: 21 Issue: 4 Pages: 341-2

    • DOI

      10.1111/nep.12610

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MicroRNA-26a inhibits TGF-β-induced extracellular matrix expression in podocytes by targeting CTGF and is downregulated in diabetic nephropathy.2015

    • Author(s)
      Koga K, Yokoi H, Mori K, Kasahara K, Kuwabara T, Imamaki H, Ishii A, Mori KP, Kato Y, Ohno S, Toda N, Saleem MA, Sugawara A, Nakao K, Yanagita M, Mukoyama M.
    • Journal Title

      Diabetologia

      Volume: 58 Issue: 9 Pages: 2169-80

    • DOI

      10.1007/s00125-015-3642-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Low Serum Neutrophil Gelatinase-associated Lipocalin Level as a Marker of Malnutrition in Maintenance Hemodialysis Patients.2015

    • Author(s)
      Imamaki H, Ishii A, Yokoi H, Kasahara M, Kuwabara T, Mori KP, Kato Y, Kuwahara T, Satoh M, Nakatani K, Saito Y, Tomosugi N, Sugawara A, Nakao K, Mukoyama M, Yanagita M, Mori K.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: 99-106

    • DOI

      10.1371/journal.pone.0132539

    • NAID

      120005678176

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Reduction of Tubular Flow Rate as a Mechanism of Oliguria in the Early Phase of Endotoxemia Revealed by Intravital Imaging.2015

    • Author(s)
      Nakano D, Doi K, Kitamura H, Kuwabara T, Mori K, Mukoyama M, Nishiyama A.
    • Journal Title

      J Am Soc Nephrol

      Volume: 26 Issue: 12 Pages: 3035-44

    • DOI

      10.1681/asn.2014060577

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An AKI biomarker lipocalin 2 in the blood derives from the kidney in renal injury but from neutrophils in normal and infected conditions.2015

    • Author(s)
      Kanda J, Mori K, Kawabata H, Kuwabara T, Mori KP, Imamaki H, Kasahara M, Yokoi H, Mizumoto C, Thoennissen NH, Koeffler HP, Barasch J, Takaori-Kondo A, Mukoyama M, Nakao K.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 19 Issue: 1 Pages: 99-106

    • DOI

      10.1007/s10157-014-0952-7

    • NAID

      120005678175

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Local inflammatory mechanism aggravated by intraglomerular crosstalk in diabetic kidney2017

    • Author(s)
      Shuro Umemoto, Takashige Kuwabara, Daisuke Fujimoto, Tomoko Kanki, Teruhiko Mizumoto, Yutaka Kakizoe, Yuichiro Izumi, Kiyoshi Mori, Masashi Mukoyama
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intraglomerular crosstalk in a mouse model of diabetic nephropathy aggravated by the renin-angiotensin system activation2017

    • Author(s)
      Shuro Umemoto, Takashige Kuwabara, Daisuke Fujimoto, Tomoko Kanki, Teruhiko Mizumoto, Yuichiro Izumi, Yutaka Kakizoe, Hirotaka Imamaki, Kiyoshi Mori, Masashi Mukoyama
    • Organizer
      World Congress of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Myeloid-specific deletion of MRP8 ameliorates glomerulonephritis through affecting macrophage characterization.2016

    • Author(s)
      Takashige Kuwabara, Kiyoshi Mori, Manabu Hayata, Shuro Umemoto, Hideki Yokoi, Masashi Mukoyama
    • Organizer
      Annual meeting 2016 of the American Society of Nephrology
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2016-11-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Intraglomerular crosstalk between mesangial cells and macrophages in glomerular injury.2016

    • Author(s)
      Shuro Umemoto, Takashige Kuwabara, Manabu Hayata, Daisuke Fujimoto, Tomoko Kanki, Yutaka Kakizoe, Yuichiro Izumi, Masashi Mukoyama
    • Organizer
      Annual meeting 2016 of the American Society of Nephrology
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2016-11-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] シンポジウム ポドサイトパチーupdate 「ポドサイトとS100ファミリー分子」2016

    • Author(s)
      桒原孝成、梅本周郎、向山政志
    • Organizer
      第46回日本腎臓学会西部学術大会
    • Place of Presentation
      シーガイアコンベンションセンター、宮崎
    • Year and Date
      2016-10-14
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] The role of activated renin-angiotensin system for the MRP8/TLR4 signaling in diabetic nephropathy.2016

    • Author(s)
      Shuro Umemoto, Takashige Kuwabara, Hirotaka Imamaki, Manabu Hayata, Yuichiro Izumi, Yutaka Kakizoe, Kiyoshi Mori, Masashi Mukoyama
    • Organizer
      The 26th Scientific Meeting of the International Society of Hypertension.
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 糖尿病マウスにおけるレニン・アンジオテンシン系亢進がMRP8/TLR4シグナルに与える影響およびその機序の検討2015

    • Author(s)
      桒原孝成、今牧博貴、森 潔、横井秀基, 向山政志
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      愛媛、ひめぎんホール
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 腎疾患および透析患者における慢性炎症の意義 ~レニン・アンジオテンシン系阻害薬の効果と合わせて~2015

    • Author(s)
      桒原孝成
    • Organizer
      第21回日本HDF研究会学術総会
    • Place of Presentation
      熊本、ホテル日航熊本
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 骨髄細胞特異的MRP8欠損はマクロファージ形質を変化させることで糸球体腎炎を軽減する2015

    • Author(s)
      桒原孝成、森 潔、横井秀基、笠原正登、柳田素子、向山政志
    • Organizer
      第58回日本腎臓学会学術総会
    • Place of Presentation
      名古屋、名古屋国際会議場
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Book] 腎疾患研究の最新の話題2017

    • Author(s)
      桒原孝成、向山政志
    • Total Pages
      2
    • Publisher
      北隆館
    • Related Report
      2017 Annual Research Report
  • [Book] 特集 腎と老化「老化と体液量調節機構」2016

    • Author(s)
      桒原孝成、向山政志
    • Total Pages
      4
    • Publisher
      科学評論社
    • Related Report
      2016 Research-status Report
  • [Book] 主治医として診る高血圧診療「BNP, NT-proBNP」2016

    • Author(s)
      桒原孝成、向山政志
    • Total Pages
      5
    • Publisher
      医学書院
    • Related Report
      2016 Research-status Report
  • [Book] 肥満関連腎臓病2016

    • Author(s)
      桒原孝成、向山政志
    • Total Pages
      5
    • Publisher
      科学評論社
    • Related Report
      2016 Research-status Report
  • [Remarks] 熊本大学腎臓内科HP

    • Related Report
      2017 Annual Research Report
  • [Remarks] 熊本大学腎臓内科HP

    • URL

      http://www.kumadai-nephrology.com/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi