| Project/Area Number |
15K09288
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
Mizuno Masashi 名古屋大学, 医学系研究科, 寄附講座教授 (20303638)
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 康弘 名古屋大学, 医学系研究科, 寄附講座講師 (20584676)
坂田 史子 名古屋大学, 医学系研究科, 特任助教 (20726484)
伊藤 恭彦 愛知医科大学, 医学部, 教授 (60402632)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 人工透析学 / 腹膜透析 / 補体活性化 / 補体制御 / 腹膜障害 / 腹膜傷害 |
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| Outline of Final Research Achievements |
Peritoneal injury is an important factor to prevent long-term peritoneal dialysis (PD), possibly following a progression of encapsulating peritoneal sclerosis (EPS) which has poor prognosis. To clarify the complement (C)-related mechanisms of development of peritoneal injuries, we have approached as an aspect of the C activation system. In the present study, we showed changes of membrane C regulators (CReg)’ expression in peritoneal mesothelium. A C activation product, we showed that sC5b-9, was useful as a surrogate maker to predict prognosis of PD-related peritonitis because peritonitis is another reason of PD withdrawal. We also developed a new peritonitis animal model to investigate mechanisms of EPS.
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