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Elucidation of the physiological role of serine protease hepsin in the kidney.

Research Project

Project/Area Number 15K09291
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKumamoto University

Principal Investigator

ADACHI MASATAKA  熊本大学, 医学部附属病院, 助教 (90398206)

Co-Investigator(Kenkyū-buntansha) 向山 政志  熊本大学, 大学院生命科学研究部(医), 教授 (40270558)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords水・電解質 / セリンプロテアーゼ / 水・電解質学 / 水・電解質代謝学
Outline of Final Research Achievements

The physiological role of serine protease hepsin, which is expressed in various human tissues including liver, spleen, and kidney, is unknown. Previous studies revealed selective increase in bone alkaline phosphatase in hepsin knockout mice. Based on reports showing the inactivation and degradation of the sodium phosphate cotransporter (NaPi-IIa) via cleavage by proteases, we hypothesized that hepsin reduces phosphate reabsorption in renal proximal tubules. We identified rat hepsin expression along the nephron segment and investigated its expression in mice with acute or chronic phosphate overload. Rat hepsin mRNA was predominantly expressed in proximal tubules, whereas lower hepsin mRNA expression levels were detected in distal and collecting duct tubules. Acute and chronic phosphate overload had no effect on mouse hepsin mRNA or hepsin protein expression in renal tubules. These findings suggested that the serine protease hepsin was not involved in phosphate handling in the kidney.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2017

All Presentation (1 results)

  • [Presentation] 食塩感受性高血圧における糸球体障害を誘導するセリンプロテアーゼについての検討2017

    • Author(s)
      岩田 康伸, 中川 輝政, 柿添 豊, 泉 裕一郎, 桑原 孝成, 安達 政隆, 北村 健一郎, 向山 政志
    • Organizer
      日本高血圧学会総会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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