EEstablishment of treatment target for ALS / FTLD
| Project/Area Number |
15K09323
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
Ito Daisuke 慶應義塾大学, 医学部(信濃町), 講師 (80286450)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 筋萎縮性側策硬化症 / 前頭側頭葉変性症 / optineurin / ubiquilin2 / 前頭側頭型認知症 / FUS / RNA結合蛋白 / 筋萎縮性側索硬化症 / TDP-43 |
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| Outline of Final Research Achievements |
1) Two different molecules involved in familial ALS, UBQLN 2 and OPTN are both involved in endosomal vesicles involved in proteolysis, have the function of connecting enodosome and autopahgy, and formed a novel protein quality control mechanism in endosome. 2) In DRP (dipeptidere peat protein) by non-AUG (RAN) translation from abnormal elongation GGGGCC repetitive sequence, expression of poly-PR, which is strongly basic, significantly reduces gemini of coiled bodies and Cajal bodies into Hela cells and suggested that it reflects the pathology of ALS.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Extremely Low Prevalence of Amyloid Positron Emission Tomography Positivity in Parkinson's Disease without Dementia.2017
Author(s)
Mashima K, Ito D, Kameyama M, Osada T, Tabuchi H, Nihei Y, Yoshizaki T, Noguchi E, Tanikawa M, Iizuka T, Date Y, Ogata Y, Nakahara T, Iwabuchi Y, Jinzaki M, Murakami K, Suzuki N
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Journal Title
Eur Neurol
Volume: 77
Issue: 5-6
Pages: 231-237
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Novel FTD model mice expressed cytoplasmic FUS in a toxic gain of function manner.2017
Author(s)
Shiihashi G, Ito D, Hayashi Y, Itohara S, Hayashi K, Nakajima K, Otsuka S, Yuzaki M, Suzuki N.
Organizer
The 13th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders,
Place of Presentation
Vienna, Austria
Year and Date
2017-03-31
Related Report
Int'l Joint Research
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