Regulation of caveolin-3 on pathomechanisms leading to muscular dystrophies
| Project/Area Number |
15K09330
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大澤 裕 川崎医科大学, 医学部, 講師 (80246511)
西松 伸一郎 川崎医科大学, 医学部, 准教授 (20222185)
藤野 雅広 川崎医療福祉大学, 医療技術学部, 講師 (50633856)
村上 龍文 川崎医科大学, 医学部, 准教授 (30330591)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKADA So-ichiro 大阪大学, 薬学研究科, 准教授 (20432445)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | シグナル伝達 / 遺伝子 / 福祉・医療 / ナノ材料 / マイクロアレイ / 医療・福祉 / カベオリン-3 / 筋ジストロフィー / 治療 |
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| Outline of Final Research Achievements |
Caveolin-3, which forms the inner membrane of the muscle cell membrane caveolae, is a scaffold protein of various signal transductions. In Duchenne muscular dystrophy (DMD), caveolin-3 is highly expressed, but its role in its pathology remains unknown. In this study, we developed caveolin-3 highly expressing DMD model mice and investigated whether caveolin-3 inhibits or promotes the dystrophic changes in DMD model mice. Both dystrophic change and myofiber atrophy were improved in caveolin-3 highly expressing DMD model mice, compared to DMD model mice. These findings indicate that caveolin-3 shows an inhibitory effects on the pathogenesis leading to DMD. We are currently elucidating the molecular mechanisms through caveolin-3.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Identification of the minimum peptide from mouse myostatin prodomain for human myostatin inhibition.2015
Author(s)
Takayama K, Noguchi Y, Aoki S, Takayama S, Yoshida M, Asari T, Yakushiji F, Nishimatsu S, Ohsawa Y, Itoh F, Negishi Y, Sunada Y, Hayashi Y
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Journal Title
J Med Chem
Volume: 58
Issue: 3
Pages: 1544-1549
DOI
Related Report
Peer Reviewed
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[Journal Article] The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy.2015
Author(s)
Ohsawa Y, Takayama K, Nishimatsu S, Okada T, Fujino M, Fukai Y, Murakami T, Hagiwara H, Itoh F, Tsuchida K, Hayashi Y, Sunada Y.
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Journal Title
PLoS One
Volume: 10
Issue: 7
Pages: e0133713-e0133713
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 筋鞘膜 nNOS はカベオリン 3 欠損による筋萎縮を抑制する2015
Author(s)
深井 雄太, 藤野雅広, 西松伸一郎, 大澤 裕, 砂田芳秀
Organizer
平成２７年度「筋ジストロフィー関連疾患の基盤的診断・治療開発研究」(26-8) 西野班 班会議
Place of Presentation
国立研究開発法人 国立精神・神経医療研究センター 教育研修棟 1Ｆ ユニバーサルホール(東京都・小平市）
Year and Date
2015-12-07
Related Report
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