| Project/Area Number |
15K09330
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Kawasaki Medical School |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
大澤 裕 川崎医科大学, 医学部, 講師 (80246511)
西松 伸一郎 川崎医科大学, 医学部, 准教授 (20222185)
藤野 雅広 川崎医療福祉大学, 医療技術学部, 講師 (50633856)
村上 龍文 川崎医科大学, 医学部, 准教授 (30330591)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
FUKADA So-ichiro 大阪大学, 薬学研究科, 准教授 (20432445)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | シグナル伝達 / 遺伝子 / 福祉・医療 / ナノ材料 / マイクロアレイ / 医療・福祉 / カベオリン-3 / 筋ジストロフィー / 治療 |
|---|
| Outline of Final Research Achievements |
Caveolin-3, which forms the inner membrane of the muscle cell membrane caveolae, is a scaffold protein of various signal transductions. In Duchenne muscular dystrophy (DMD), caveolin-3 is highly expressed, but its role in its pathology remains unknown. In this study, we developed caveolin-3 highly expressing DMD model mice and investigated whether caveolin-3 inhibits or promotes the dystrophic changes in DMD model mice. Both dystrophic change and myofiber atrophy were improved in caveolin-3 highly expressing DMD model mice, compared to DMD model mice. These findings indicate that caveolin-3 shows an inhibitory effects on the pathogenesis leading to DMD. We are currently elucidating the molecular mechanisms through caveolin-3.
|
