| Project/Area Number |
15K09333
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
Masahiro Mori 千葉大学, 大学院医学研究院, 准教授 (70345023)
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| Co-Investigator(Kenkyū-buntansha) |
鵜沢 顕之 千葉大学, 医学部附属病院, 助教 (10533317)
日和佐 隆樹 千葉大学, 大学院医学研究院, 准教授 (30260251)
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| Research Collaborator |
UCHIDA Tomohiko 千葉大学, 大学院医学研究院, 医員
MASUDA Hiroki 千葉大学, 大学院医学研究院, 特任助教
OHTANI Ryouhei 千葉大学, 大学院医学研究院, 医員
LIU Jia 千葉大学, 大学院医学研究院, 大学院生
SUGIMOTO Manabu 千葉大学, 大学院医学研究院, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 多発性硬化症 / talin-1 / 自己抗体 / 神経免疫疾患 / SEREX法 / ｔａｌｉｎ１ / 抗talin-1抗体 / バイオマーカー / talin / プロテインアレイ法 / SEREX |
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| Outline of Final Research Achievements |
We measured titers of antibodies against talin-1(TLN1) identified by SEREX and concentrations of soluble form of TLN1 (sTLN1) in large scale of multiple sclerosis (MS) patients, and normal controls. The results showed both anti-TLN1 antibody titers and sTLN1 were significantly higher in MS patients than in normal controls. In conclusion, novel autoantibodies against TLN1 can be found in sera from some MS patients; the production of serum anti-TLN1 antibody in MS is thought to be caused not by response to elevation of sTLN1.
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