Brain connectome change associated with propagation of amyloid beta in Alzheimer's disease.
| Project/Area Number |
15K09353
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
上原 平 九州大学, 医学研究院, 助教 (30631585)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | アルツハイマー病 / 安静時機能的MRI / 脳コネクトーム / 認知症 / 機能的MRI |
|---|
| Outline of Final Research Achievements |
This study aimed to elucidate asscoation brai connectome change and paropagation of beta amyloid protein. We revealed the assciation impairment of orientation for time and dysconnection from posterior cingulate gyrus to riht middle temporal gyrus. We intended to elucidate the relation functional connectivity change and pathologoical change associated with other higer fuction including memory impairment. furthermore we will investigate the pathlogivcal change according to the connectome of AD using PET in future.
|
Report
(4 results)
Research Products
(4 results)
-
[Journal Article] Functional connectivity change between posterior cingulate cortex and ventral attention network relates to the impairment of orientation for time in Alzheimer's disease patients.2018
Author(s)
Yamashita KI, Uehara T, Prawiroharjo P, Yamashita K, Togao O, Hiwatashi A, Taniwaki Y, Utsunomiya H, Matsushita T, Yamasaki R, Kira JI.
-
Journal Title
Brain imaging and behavior
Volume: in press
Related Report
Peer Reviewed
-
-
-
