Brain connectome change associated with propagation of amyloid beta in Alzheimer's disease.

Research Project

Project/Area Number	15K09353
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Neurology
Research Institution	Kyushu University
Principal Investigator	Yamashita Kenichiro 九州大学, 大学病院, 助教 (00596687)
Co-Investigator(Kenkyū-buntansha)	上原平九州大学, 医学研究院, 助教 (30631585)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	アルツハイマー病 / 安静時機能的MRI / 脳コネクトーム / 認知症 / 機能的MRI
Outline of Final Research Achievements	This study aimed to elucidate asscoation brai connectome change and paropagation of beta amyloid protein. We revealed the assciation impairment of orientation for time and dysconnection from posterior cingulate gyrus to riht middle temporal gyrus. We intended to elucidate the relation functional connectivity change and pathologoical change associated with other higer fuction including memory impairment. furthermore we will investigate the pathlogivcal change according to the connectome of AD using PET in future.