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Differentiation of early Alzheimer's disease by the diffusion kurtosis imaging

Research Project

Project/Area Number 15K09357
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionIwate Medical University

Principal Investigator

Takahashi Junko  岩手医科大学, 医学部, 助教 (00423989)

Co-Investigator(Kenkyū-buntansha) 米澤 久司  岩手医科大学, 医学部, 准教授 (20240377)
寺山 靖夫  岩手医科大学, 医学部, 教授 (70146596)
佐々木 真理  岩手医科大学, 医学部, 教授 (80205864)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsアルツハイマー病 / 軽度認知障害 / MRI / 拡散尖度画像 / 拡散テンソル画像 / 拡散尖度イメージング / 拡散テンソルイメージング / 帯状束
Outline of Final Research Achievements

By identifying cases that progress to Alzheimer's disease (AD) more accurately at the mild cognitive impairment (MCI) stage it becomes possible to extract more appropriate cases when curative drugs are used. In this study, the parahippocampal cingulum bundles were three dimensionally extracted using MRI, and the mean parameter within the volume was automatically measured. When comparing between patients with MCI and healthy subjects, significant differences were observed in the mean kurtosis(MK), mean diffusivity(MD) in the parahippocampal cingulum bundle. In the ROC analysis of patients with MCI and the healthy subjects, the sensitivity and specificity were 65.0% and 85%, respectively, when the cut-off value was 0.69, whereas for the MD, the sensitivity and specificity were 84.6% and 75%, respectively, when the cut-off value was 0.87. When combining MD and MK measurements, the difference between patients with MCI and the healthy subjects could be more accurately distinguished.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2015

All Presentation (2 results)

  • [Presentation] 認知機能検査と事象関連電位P300の関連性の検討2015

    • Author(s)
      高橋純子、石塚直樹、藤澤豊、鈴木真紗子、小原智子、柴田俊秀、工藤雅子、米澤久司、寺山靖夫
    • Organizer
      第6回日本脳血管・認知症学会 学術集会
    • Place of Presentation
      TFTビル(東京都江東区)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] アルツハイマー病の白質病変と事象関連電位P300の関連生の検討2015

    • Author(s)
      高橋純子、石塚直樹、藤澤豊、鈴木真紗子、小原智子、柴田俊秀、工藤雅子、米澤久司、寺山靖夫
    • Organizer
      第6回日本脳血管・認知症学会 学術集会
    • Place of Presentation
      TFTビル(東京都江東区)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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