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Complex energy absorption process analysis by lipidomics

Research Project

Project/Area Number 15K09401
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

Hakamata Hideki  東京薬科大学, 薬学部, 教授 (70284750)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsエネルギー・糖質代謝異常 / 膜輸送と輸送タンパク質 / リピドミクス
Outline of Final Research Achievements

Among omics methods for the quantification/qualification of biological substances, this study is oriented to clarify the mechanisms for the intestinal energy absorption by lipidomics. By selecting nineteen types of lipid as analytes, a new lipidomics method was developed by liquid chromatography ion-trap time-of-flight mass spectrometry (LC-IT-TOF-MS). Real sample analysis showed that linoleic acid, lysophosphatidylcholines, phosphatidylcholines and triacylglycerols in enteral nutrition Twinline were detected by LC-IT-TOF-MS.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) (of which Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Determination of serum brassicasterol in spontaneously hypertensive rats stroke-prone fed a high-ergosterol diet by ultra performance liquid chromatography.2016

    • Author(s)
      Ohtsubo, T., Kageyama, R., Koseki, Y., Hagi, J., Kotani, A., Yamamoto, K., Kusu, F., Miura, T., Hakamata, H.
    • Journal Title

      Eur. J. Lipid Sci. Technol.

      Volume: 118 Issue: 7 Pages: 1074-1083

    • DOI

      10.1002/ejlt.201400578

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] LC-IT-TOF-MSによるリピドミクスのための脂質イオン化パターンの同定2017

    • Author(s)
      袴田秀樹、石田萌実、山本法央、小谷 明
    • Organizer
      第6回医薬工包括連携推進シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] エルゴステロールとブラジカステロールの重水素標識体の合成及び液体クロマトグラフィー-質量分析法による定量法の開発2017

    • Author(s)
      町田晃一、古石裕治、小谷明、山本法央、三浦剛、袴田秀樹
    • Organizer
      平成29年度 日本分析化学会関東支部若手交流会
    • Related Report
      2017 Annual Research Report
  • [Presentation] SHRSPラット血中のエルゴステロール-d1及びブラジカステロール-d1のLC-MS/MSによる定量2017

    • Author(s)
      町田晃一、古石裕治、小谷明、山本法央、三浦剛、袴田秀樹
    • Organizer
      第30回バイオメディカル分析科学シンポジウム(BMAS 2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] メタボロームを指向したアンペロメトリック検出法の開発と質量分析法との比較2016

    • Author(s)
      袴田秀樹
    • Organizer
      第10回メタボロームシンポジウム
    • Place of Presentation
      山形
    • Year and Date
      2016-10-20
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] LC-IT-TOF-MSによる経腸栄養剤中脂質の検出2015

    • Author(s)
      石田萌実、花光真里奈、山本法央、小谷 明、袴田秀樹
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] LC-IT-TOF-MSによる血清脂質のマスクロマトグラム測定2015

    • Author(s)
      花光真里奈、山本法央、小谷 明、袴田秀樹
    • Organizer
      第28回バイオメディカル分析科学シンポジウム(BMAS 2015)
    • Place of Presentation
      長崎
    • Year and Date
      2015-08-21
    • Related Report
      2015 Research-status Report
  • [Book] 薬学生のための分析化学2017

    • Author(s)
      楠 文代,渋澤庸一 編集
    • Total Pages
      340
    • Publisher
      廣川書店
    • ISBN
      9784567255837
    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://www.ps.toyaku.ac.jp/wp/bunsekikagaku/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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