Serum markers for early diagnosis of fulminant type 1 diabetes

• Project/Area Number: 15K09402
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Osaka Medical College
• Principal Investigator: Hanafusa Toshiaki 大阪医科大学, その他部局等, 名誉教授 (60164886)
• Co-Investigator(Kenkyū-buntansha): 佐野 寛行 大阪医科大学, 医学部, 助教 (20556435)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 劇症1型糖尿病 / 抗ＣＤ300e抗体 / Seromic analysis / 抗CD300ｅ抗体 / Ｓｅｒｏｍｉｃ ａｎａｌｙｓｉｓ / 抗ＣＤ３００e抗体 / 新規抗体

Outline of Final Research Achievements

The present study clarified a novel biomarker anti-CD300e antibody to diagnose fulminant type 1 diabetes (FT1D). Seromic analysis revealed 9 antibodies which showed high signals in sera from patients with FT1D in acute phase. Among them, the titre of anti-CD300e antibody was significantly higher in FT1D patients in acute phase than that in autoimmune type 1 diabetes (T1AD), type 2 diabetes (T2D), autoimmune thyroid disease (AITD) patients and healthy controls (HC) by ELISA.

Research Products

• [Journal Article] Antibody to CMRF35-Like Molecule 2, CD300e A Novel Biomarker Detected in Patients with Fulminant Type 1 Diabetes. (2016)
  • Author(s): Haseda F, Imagawa A, Nishikawa H, Mitsui S, Tsutsumi C, Fujisawa R, Sano H, Murase-Mishiba Y, Terasaki J, Sakaguchi S, Hanafusa T.
  • Journal Title: PLOS ONE Volume: 11 Issue: 8 Pages: e0160576-e0160576
  • DOI: 10.1371/journal.pone.0160576
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 劇症1型糖尿病患者急性期血清において上昇を認めた新規抗体、抗CD300e抗体 (2018)
  • Author(s): 長谷田文孝、西川博嘉、三井しのぶ、堤千春、藤澤玲子、佐野寛行、三柴裕子、寺前純吾、坂口志文、花房俊昭、今川彰久、
  • Organizer: 第61回日本糖尿病学会 年次学術集会
• [Presentation] 劇症1型糖尿病患者急性期血清において高値を認める新規抗体 (2015)
  • Author(s): 長谷田文孝、今川彰久、西川博嘉、三井しのぶ、藤澤玲子、堤千春、佐野寛行、三柴裕子、寺前純吾、坂口志文、花房俊昭
  • Organizer: 第58回日本糖尿病学会 年次学術集会
  • Place of Presentation: ぱしふぃっくびいなす（山口県下関市）
  • Year and Date: 2015-05-21